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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Kinesin-like protein 1' and Ligand = 'BDBM50322579'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50322579
PNG
(2-(trifluoromethyl)-9H-carbazole | CHEMBL1173704)
Show SMILES FC(F)(F)c1ccc2c(c1)[nH]c1ccccc21
Show InChI InChI=1S/C13H8F3N/c14-13(15,16)8-5-6-10-9-3-1-2-4-11(9)17-12(10)7-8/h1-7,17H
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Article
PubMed
n/an/a 210n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged KSP ATPase motor domain (unknown origin) expressed in bacteria incubated for 30 mins prior to ATP addition measur...


Bioorg Med Chem 22: 3171-9 (2014)


Article DOI: 10.1016/j.bmc.2014.04.008
BindingDB Entry DOI: 10.7270/Q2ST7RD5
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50322579
PNG
(2-(trifluoromethyl)-9H-carbazole | CHEMBL1173704)
Show SMILES FC(F)(F)c1ccc2c(c1)[nH]c1ccccc21
Show InChI InChI=1S/C13H8F3N/c14-13(15,16)8-5-6-10-9-3-1-2-4-11(9)17-12(10)7-8/h1-7,17H
PDB
MMDB

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CHEMBL
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PC sid
UniChem

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Article
PubMed
n/an/a 210n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of C-terminally His6-tagged microtubule-activated KSP motor domain ATPase activity after 15 mins by luciferase-derived luminescence assay


J Med Chem 54: 4839-46 (2011)


Article DOI: 10.1021/jm200448n
BindingDB Entry DOI: 10.7270/Q20V8D5G
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM50322579
PNG
(2-(trifluoromethyl)-9H-carbazole | CHEMBL1173704)
Show SMILES FC(F)(F)c1ccc2c(c1)[nH]c1ccccc21
Show InChI InChI=1S/C13H8F3N/c14-13(15,16)8-5-6-10-9-3-1-2-4-11(9)17-12(10)7-8/h1-7,17H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of human C-terminally His6-tagged microtubule-activated KSP motor domain ATPase activity after 30 mins by luciferase-derived luminescence ...


J Med Chem 53: 5054-8 (2010)


Article DOI: 10.1021/jm100476d
BindingDB Entry DOI: 10.7270/Q23X86T4
More data for this
Ligand-Target Pair