Compile Data Set for Download or QSAR
Found 1 Enz. Inhib. hit(s) with Target = 'Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S]' and Ligand = 'BDBM548489'
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
MERCK SHARP & DOHME LLC

WIPO
LigandPNGBDBM548489(WO2022093881, Ex-9.19)
Show SMILES Cc1cc2cnc(NC(=O)C3CC3c3ccccn3)cc2cc1N1CCN(CC1)C1(C)COCC1F
Show InChI InChI=1S/C28H32FN5O2/c1-18-11-20-15-31-26(32-27(35)22-14-21(22)23-5-3-4-6-30-23)13-19(20)12-24(18)33-7-9-34(10-8-33)28(2)17-36-16-25(28)29/h3-6,11-13,15,21-22,25H,7-10,14,16-17H2,1-2H3,(H,31,32,35)
Affinity DataIC50: 0.0800nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed