Compile Data Set for Download or QSAR
Found 1 Enz. Inhib. hit(s) with Target = 'Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S]' and Ligand = 'BDBM548515'
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
MERCK SHARP & DOHME LLC

WIPO
LigandPNGBDBM548515(WO2022093881, Ex-10.24)
Show SMILES CCO[C@H]1C[C@@]2(C[C@@H]2C(=O)Nc2cc3cc(N4CCN(CC4)[C@]4(C)COC[C@@H]4F)c(Cl)cc3cn2)C1
Show InChI InChI=1S/C27H34ClFN4O3/c1-3-36-19-11-27(12-19)13-20(27)25(34)31-24-10-17-9-22(21(28)8-18(17)14-30-24)32-4-6-33(7-5-32)26(2)16-35-15-23(26)29/h8-10,14,19-20,23H,3-7,11-13,15-16H2,1-2H3,(H,30,31,34)/t19-,20-,23+,26-,27-/m1/s1
Affinity DataIC50: 0.0800nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed