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Found 7 Enz. Inhib. hit(s) with Target = 'Lysine-specific demethylase 5B' and Ligand = 'BDBM195608'
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  3nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  3nMAssay Description:Inhibition of KDM5B (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length human KDM5B expressed in baculovirus expression system using (ARTK(me3)QTARKSTGGKAPRKQLA peptide substMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  3nMAssay Description:Inhibition of KDM5B (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  10nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5B expressed in Sf9 insect cells using biotin-H3K4me as substrate by ALPHAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Genentech

LigandPNGBDBM195608(CPI-455)
Affinity DataIC50:  337nMAssay Description:Inhibition of human N-terminal FLAG/His-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-21)K4(Me3)-GGK...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed