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Found 13 Enz. Inhib. hit(s) with Target = 'Lysosomal acid glucosylceramidase' and Ligand = 'BDBM18351'
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  4.70E+4nMAssay Description:Inhibitory activity against beta-glucosidase of sweet almondMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  7.90E+4nM ΔG°:  -24.4kJ/mole IC50:  2.40E+5nMpH: 5.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  7.90E+4nMAssay Description:Inhibition of human lysosomal beta-glucocerebrosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  3.00E+5nMpH: 5.0Assay Description:Competitive Inhibition constant of the compound was determined on almonds beta Glucosidase at pH 5.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  3.00E+5nMpH: 5.0Assay Description:Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 7.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  1.18E+5nMAssay Description:Inhibitory activity was determined against Escherichia coli Alpha-galactosidaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  1.95E+5nMAssay Description:Inhibition of human beta-glucocerebrosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Bos taurus)
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  2.10E+5nMAssay Description:Inhibition of bovine liver beta-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  2.40E+5nMAssay Description:Inhibition of human lysosomal beta-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  2.40E+5nMAssay Description:Inhibition of human GCase assessed as reduction of 4-methylumbelliferone liberation using 4-methylumbelliferyl-beta-glucopyranoside as substrate prei...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibitory activity was determined against Escherichia coli beta galactosidaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of Beta-glucosidase activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  5.06E+5nMAssay Description:Displacement of 4-methylumbelliferyl from human GBA by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed