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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 4' and Ligand = 'BDBM504273'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM504273
PNG
((5S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phe...)
Show SMILES CN1C(=O)N(C(=O)C[C@]11CCc2ncccc12)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C26H19F2N3O2/c1-30-25(33)31(23(32)16-26(30)12-11-22-19(26)8-5-13-29-22)24-20(27)14-18(15-21(24)28)10-9-17-6-3-2-4-7-17/h2-8,13-15H,11-12,16H2,1H3/t26-/m0/s1
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US Patent
n/an/an/an/a 94n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US11034699 (2021)

More data for this
Ligand-Target Pair