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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 4' and Ligand = 'BDBM504285'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM504285
PNG
((8S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phe...)
Show SMILES CCN1C(=O)N(C(=O)C[C@]11CCCc2ccncc12)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C28H23F2N3O2/c1-2-32-27(35)33(25(34)17-28(32)13-6-9-21-12-14-31-18-22(21)28)26-23(29)15-20(16-24(26)30)11-10-19-7-4-3-5-8-19/h3-5,7-8,12,14-16,18H,2,6,9,13,17H2,1H3/t28-/m0/s1
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US Patent
n/an/an/an/a 114n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US11034699 (2021)

More data for this
Ligand-Target Pair