Found 4 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50443085' TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 5.60nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 StaR domain (569 to 836 residues) (unknown origin) expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
3D Structure (crystal)TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
