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Found 4 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 11' and Ligand = 'BDBM50441570'
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441570(CHEMBL2436976 | US10485800, Example 17 | US9814704...)
Affinity DataIC50:  9nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441570(CHEMBL2436976 | US10485800, Example 17 | US9814704...)
Affinity DataIC50: <100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441570(CHEMBL2436976 | US10485800, Example 17 | US9814704...)
Affinity DataIC50: <100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 11(Mus musculus)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50441570(CHEMBL2436976 | US10485800, Example 17 | US9814704...)
Affinity DataIC50:  990nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed