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Found 40 Enz. Inhib. hit(s) with Target = 'Mu-type opioid receptor' and Ligand = 'BDBM50008984'
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  0.390nMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(MOUSE)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(MOUSE)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  0.940nMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to mu opioid receptor (unknown origin) expressed in HEK cells at pH 7.4More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor measured after 2 hrs by competitive binding assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity of compound evaluated for Opioid receptor mu 1 isolated from rat brainMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  2.20nMAssay Description:Ability to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from the rat brain membranes.More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  2.20nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]-DAMGO (2 nM ) from opioid receptor mu 1 in human brainMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  4nMAssay Description:Binding affinity against Opioid receptor mu 1More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards Opioid receptor mu 1 using [3H]DAMGO as radioligand.More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membrane incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(MOUSE)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]-DAMGO from Swiss Webster mouse neural membranes mu opioid receptor after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranesMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  8.5nMAssay Description:Binding affinity against mu opioid receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  570nMAssay Description:Displacement of [3H] DAMGO from rat mu-opioid receptorMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligandMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  1.90nMAssay Description:Agonist activity at mu opioid receptor in Hartley guinea pig ileum/longitudinal muscle with myenteric plexus assessed as inhibition of PL-017-induced...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  3.10nMAssay Description:Compound was tested in vitro for binding affinity towards mu opioid receptor by measuring displacement of [3H]-DAGO from guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMu-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  3.10nMAssay Description:In vitro binding activity against opioid receptor mu using [3H]-DAGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  3.40nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically stimulated muscle contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  3.45nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  5.5nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 mea...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  9.5nMAssay Description:Agonist activity at mu opioid receptor in beta-funaltrexamine-treated guinea pig isolated ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  11nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 7.4 mea...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  1.26E+3nMAssay Description:Displacement of [3H] DAMGO from rat mu-opioid receptorMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(GUINEA PIG)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  3.40E+3nMAssay Description:Agonist activity at mu opioid receptor in guinea pig isolated ileum assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataEC50:  32nMAssay Description:Compound was tested for its ability to stimulate [35S]GTP-gamma-S, binding to membranes from C6 glioma cells stably expressing rat mu opioid receptorMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataEC50:  17nMAssay Description:Agonist activity at mu opioid receptor (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation ...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataEC50:  17nMAssay Description:Agonist activity at mu opioid receptor (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation ...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataEC50:  0.510nMAssay Description:Agonist activity at human MOR expressed in CHO-K1 cells assessed as cAMP accumulation incubated for 30 mins and measured after 1 hr by Eu-cAMP tracer...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataEC50:  43nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cell membranes after 1 hr by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataEC50:  53nMAssay Description:Agonist activity at human mu opioid receptor expressed in human U2OS cells co-transfected with beta-arrestin-2 assessed as increase in beta-arrestin-...More data for this Ligand-Target Pair