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Found 3 Enz. Inhib. hit(s) with Target = 'N-lysine methyltransferase SMYD2' and Ligand = 'BDBM378654'
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM378654(N-{1-[(1-benzyl-1H-pyrazol-4-yl)methyl]azetidin-3-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of FLAG and C-terminally Avi-tagged full length SMYD2 (unknown origin) expressed in Sf9 cells using SAM and histone H3 (1 to 29 residues) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM378654(N-{1-[(1-benzyl-1H-pyrazol-4-yl)methyl]azetidin-3-...)
Affinity DataIC50:  16.4nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM378654(N-{1-[(1-benzyl-1H-pyrazol-4-yl)methyl]azetidin-3-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human SMYD2 overexpressing human KYSE-150 cells assessed as SMYD2 assessed as reduction in BTF3 monomethylation by Western blot analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed