Compile Data Set for Download or QSAR
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Found 3 Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2' and Ligand = 'BDBM50261215'
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261215(CHEMBL2387223)
Affinity DataKi:  1.60nMAssay Description:Inhibition of TYK2 (unknown origin) assessed as reduction in IL-23 induced STAT3 phosphorylation by cell based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261215(CHEMBL2387223)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of JAK2 (unknown origin) assessed as reduction in EPO-mediated STAT5 phosphorylation by cell based readout assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261215(CHEMBL2387223)
Affinity DataEC50:  224nMAssay Description:Inhibition of TYK2 (unknown origin) assessed as reduction in IL-12 induced STAT4 phosphorylation by cell based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed