Found 7 Enz. Inhib. hit(s) with Target = 'Nuclear receptor subfamily 1 group I member 2' and Ligand = 'BDBM429599' TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Rsearch Hospital
US Patent
St. Jude Children''S Rsearch Hospital
US Patent
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Rsearch Hospital
US Patent
St. Jude Children''S Rsearch Hospital
US Patent
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Rsearch Hospital
US Patent
St. Jude Children''S Rsearch Hospital
US Patent
Affinity DataIC50: 1.52E+3nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Rsearch Hospital
US Patent
St. Jude Children''S Rsearch Hospital
US Patent
Affinity DataIC50: 1.52E+3nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Rsearch Hospital
US Patent
St. Jude Children''S Rsearch Hospital
US Patent
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs in pres...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Rsearch Hospital
US Patent
St. Jude Children''S Rsearch Hospital
US Patent
Affinity DataIC50: 4.00E+3nMAssay Description:Displacement of BODIPY FL vindoline from GST-tagged human PXR LBD incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Rsearch Hospital
US Patent
St. Jude Children''S Rsearch Hospital
US Patent
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs by lucifer...More data for this Ligand-Target Pair
