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Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Plasminogen' and Ligand = 'BDBM50357211'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen


(Homo sapiens (Human))
BDBM50357211
PNG
(177 J.D. | AMINOCAPROIC ACID | Amicar | Aminocapro...)
Show SMILES NCCCCCC(O)=O
Show InChI InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
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5.30E+7n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) assessed as reduction in amidolytic activity


J Med Chem 63: 1445-1472 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01060
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (Human))
BDBM50357211
PNG
(177 J.D. | AMINOCAPROIC ACID | Amicar | Aminocapro...)
Show SMILES NCCCCCC(O)=O
Show InChI InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
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PubMed
n/an/a 4.00E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA


ACS Med Chem Lett 5: 538-43 (2014)


Article DOI: 10.1021/ml400526d
BindingDB Entry DOI: 10.7270/Q2QJ7JV4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (Human))
BDBM50357211
PNG
(177 J.D. | AMINOCAPROIC ACID | Amicar | Aminocapro...)
Show SMILES NCCCCCC(O)=O
Show InChI InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
PDB
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Article
PubMed
n/an/a 1.05E+5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...


ACS Med Chem Lett 5: 538-43 (2014)


Article DOI: 10.1021/ml400526d
BindingDB Entry DOI: 10.7270/Q2QJ7JV4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (Human))
BDBM50357211
PNG
(177 J.D. | AMINOCAPROIC ACID | Amicar | Aminocapro...)
Show SMILES NCCCCCC(O)=O
Show InChI InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
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CHEBI
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

DrugBank
PDB
Article
PubMed
n/an/an/a 9.00E+3n/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Binding affinity to human plasminogen K1 domain by ultrafiltration technique


J Med Chem 63: 1445-1472 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01060
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)