Compile Data Set for Download or QSAR
Found 1 Enz. Inhib. hit(s) with Target = 'Prolyl hydroxylase EGLN3' and Ligand = 'BDBM93433'
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Amgen Inc

LigandPNGBDBM93433(PHD Inhibitor, 12{2,1,4})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc4ccccc4c3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C41H43N5O8/c1-41(2,3)40(54)45-31(21-25-14-16-27-12-8-9-13-28(27)18-25)37(51)44-30(20-24-10-6-5-7-11-24)36(50)42-22-26-15-17-32-29(19-26)35(49)34(39(53)46(32)4)38(52)43-23-33(47)48/h5-19,30-31,49H,20-23H2,1-4H3,(H,42,50)(H,43,52)(H,44,51)(H,45,54)(H,47,48)/t30-,31-/m1/s1
Affinity DataIC50: 18.8nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair