BindingDB PrimarySearch

Found 36 Enz. Inhib. hit(s) with Target = 'Protease' and Ligand = 'BDBM8125'

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.000200nMAssay Description:Inhibition of wild type HIV1 protease by FRET assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.00147nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.00500nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.00530nMAssay Description:Inhibition of wild-type HIV1 BH10 protease expressed in Escherichia coli by spectrophotometric assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.00800nMAssay Description:Binding affinity to wild type HIV1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.00800nMAssay Description:Inhibition of wild type HIV1 protease by FRETMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0100nMAssay Description:Inhibition of HIV1 protease using RE(Edans)SGIFLETSK(Dabcyl)R as substrate by fluorescence methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV-1 protease by fluorometric assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV1 wild type NL4-3 protease expressed in Escherichia coli Rosetta (DE3) pLysS using Abz-Thr-Ile-Nle-Phe-(pNO2)-Gln-Arg-NH2 as substra...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of wild type HIV-1 NL4-3 protease expressed in Escherichia coli Rosetta (DE3)pLysS using Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fl...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV1 protease using Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 substrate by continuous fluorometric assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV1 protease dimerization in MT2 cellsMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0250nMAssay Description:Inhibition of HIV1 NL4-3 protease I84V mutant expressed in Escherichia coli TAP-106 cells using EDANS/DABCYL-labelled 10-amino acid containing natura...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0750nMAssay Description:Inhibition of HIV1 NL4-3 protease I50V/A71V mutant expressed in Escherichia coli TAP-106 cells using EDANS/DABCYL-labelled 10-amino acid containing n...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.340nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 1.10nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 9nMAssay Description:Inhibition of wild type HIV1 protease by enzyme inhibitionMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 18nMAssay Description:Inhibition of wild type HIV1 protease by uncompetitive bindingMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 22nMAssay Description:Inhibition of wild type HIV1 protease by competitive bindingMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

IC50: 0.0130nMAssay Description:Inhibition of GAR transformylase from Lactobacillus caseiMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

IC50: 0.0600nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli using Arg-Glu (EDANS)-Ser-GlnAsn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-Arg as substrate preincuba...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

IC50: 0.0610nMT: 2°CAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli incubated for 20 to 30 mins at room temperature using (Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-I...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

IC50: 0.460nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli using Arg-Glu (EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-Arg as substrate preincub...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

IC50: 1.10nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli using Arg-Glu (EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-Arg as substrate preincub...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

IC50: 3.80nMAssay Description:Inhibition of Human immunodeficiency virus 1 3B proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

IC50: 4nMAssay Description:Inhibition of wild type HIV1 protease expressed in Escherichia coli using Arg-Glu (EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-Arg as substrat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Kd: 0.0160nMAssay Description:Binding affinity to HIV1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

EC50: 13nMAssay Description:Inhibition of DRV-resistant protease V32I/L33F/I54M/V82I mutant in HIV1 transfected in 293T cells after 48 hrs by lentiviral vector-based luciferase ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

EC50: 112nMAssay Description:Inhibition of DRV-resistant protease V32I/L33F/I54M/I84V mutant in HIV1 transfected in 293T cells after 48 hrs by lentiviral vector-based luciferase ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Filter my 36 hits

Targets 1▿
- Protease 36
Publications 31▿
- J Med Chem 51: 6599-603 (2008) 3
- J Med Chem 63: 8296-8313 (2020) 2
- J Med Chem 61: 5138-5153 (2018) 2
- J Med Chem 62: 8062-8079 (2019) 2
- J Med Chem 62: 9375-9414 (2019) 1
- J Med Chem 59: 4171-88 (2016) 1
- J Med Chem 61: 9722-9737 (2018) 1
- Bioorg Med Chem 15: 7576-80 (2007) 1
- J Biol Chem 282: 28709-20 (2007) 1
- J Med Chem 51: 4839-43 (2008) 1
- J Med Chem 50: 4509-15 (2007) 1
- J Med Chem 53: 7699-708 (2010) 1
- J Med Chem 55: 3387-97 (2012) 1
- ACS Med Chem Lett 8: 1292-1297 (2017) 1
- J Med Chem 58: 6994-7006 (2015) 1
- Bioorg Med Chem Lett 29: 357-361 (2019) 1
- Bioorg Med Chem Lett 29: 1541-1545 (2019) 1
- Bioorg Med Chem Lett 29: 2565-2570 (2019) 1
- Bioorg Med Chem Lett 20: 1241-6 (2010) 1
- ACS Med Chem Lett 2: 461-5 (2011) 1
- J Med Chem 53: 607-15 (2010) 1
- Eur J Med Chem 185: (2020) 1
- J Med Chem 59: 2849-78 (2016) 1
- Bioorg Med Chem Lett 25: 4903-4909 (2015) 1
- J Med Chem 61: 4561-4577 (2018) 1
- Antimicrob Agents Chemother 51: 3147-54 (2007) 1
- Eur J Med Chem 137: 30-44 (2017) 1
- J Med Chem 55: 6328-41 (2012) 1
- Bioorg Med Chem Lett 25: 1880-3 (2015) 1
- J Med Chem 58: 5088-95 (2015) 1
- J Med Chem 63: 4867-4879 (2020) 1
Institutions 15▿
- Purdue University 8
- Georgia State University 6
- University Of Massachusetts Medical School 5
- Chinese Academy Of Medical Science And Peking Union Medical College 4
- Shandong University 2
- Kobe Gakuin University 2
- Glaxosmithkline 1
- Kumamoto University Graduate School Of Medical And Pharmaceutical Sciences 1
- Uppsala University 1
- Chinese Academy Of Medical Sciences And Peking Union Medical College 1
- University Of Southampton 1
- Sanford-Burnham Medical Research Institute 1
- Harvard University 1
- Academy Of Sciences Of The Czech Republic 1
- Merck 1
Affinity: 0.00020 to 1.1E+2 nM▿
- Ki 26
- IC50 7
- Kd 1
- EC50 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1