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Found 5 Enz. Inhib. hit(s) with Target = 'Protein-tyrosine kinase 2-beta' and Ligand = 'BDBM50301356'
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human Pyk2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human PyK2 Y402 autophosphorylation expressed in 293T cells by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in osteocalcin levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataEC50:  10nMAssay Description:Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in alkaline phosphatase levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed