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Found 6 Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase Src' and Ligand = 'BDBM50345739'
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345739(1-isopropyl-3-(6-methoxynaphthalen-2-yl)-1H-pyrazo...)
Affinity DataKi:  770nMAssay Description:Inhibition of human SRC by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345739(1-isopropyl-3-(6-methoxynaphthalen-2-yl)-1H-pyrazo...)
Affinity DataIC50:  576nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345739(1-isopropyl-3-(6-methoxynaphthalen-2-yl)-1H-pyrazo...)
Affinity DataIC50:  670nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphorimaging methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345739(1-isopropyl-3-(6-methoxynaphthalen-2-yl)-1H-pyrazo...)
Affinity DataIC50:  770nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345739(1-isopropyl-3-(6-methoxynaphthalen-2-yl)-1H-pyrazo...)
Affinity DataIC50:  770nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345739(1-isopropyl-3-(6-methoxynaphthalen-2-yl)-1H-pyrazo...)
Affinity DataIC50:  770nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent