Found 5 Enz. Inhib. hit(s) with Target = 'Rap guanine nucleotide exchange factor 3' and Ligand = 'BDBM50280395' TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases
Curated by ChEMBL
Institute For Research In Cancer And Allied Diseases
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases
Curated by ChEMBL
Institute For Research In Cancer And Allied Diseases
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Antagonist activity at recombinant human GST-fused EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta (DE3) assessed as inhibition of ...More data for this Ligand-Target Pair
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases
Curated by ChEMBL
Institute For Research In Cancer And Allied Diseases
Curated by ChEMBL
Affinity DataIC50: 5.50E+3nMAssay Description:Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases
Curated by ChEMBL
Institute For Research In Cancer And Allied Diseases
Curated by ChEMBL
Affinity DataKd: 7.57E+5nMAssay Description:Binding affinity to human EPAC1 cAMP binding domain (149 to 318 residues) in presence of human serum albumin by [15N-1H]HSQC spectroscopic analysisMore data for this Ligand-Target Pair
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute For Research In Cancer And Allied Diseases
Curated by ChEMBL
Institute For Research In Cancer And Allied Diseases
Curated by ChEMBL
Affinity DataKd: 1.24E+5nMAssay Description:Binding affinity to human EPAC1 cAMP binding domain (149 to 318 residues) by [15N-1H]HSQC spectroscopic analysisMore data for this Ligand-Target Pair
