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Found 4 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1ab' and Ligand = 'BDBM525250'
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525250(N-[(1S)-1-(1-bicyclo[1.1.1]pentanylmethyl)-2-[2-[(...)
Affinity DataIC50:  21nMAssay Description: For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(HCoV-229E)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525250(N-[(1S)-1-(1-bicyclo[1.1.1]pentanylmethyl)-2-[2-[(...)
Affinity DataIC50:  24nMAssay Description:For the HCoV-229E 3CLpro assay, 2 μL of 0.02 μM recombinant HCoV-229E 3CL protease were mixed with serial dilutions of each com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525250(N-[(1S)-1-(1-bicyclo[1.1.1]pentanylmethyl)-2-[2-[(...)
Affinity DataIC50:  71nMAssay Description:For the SARS-CoV-2 3CLpro assay, 2 μL of 0.02 μM recombinant SARS-CoV-2 3CL protease were mixed with serial dilutions of each c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525250(N-[(1S)-1-(1-bicyclo[1.1.1]pentanylmethyl)-2-[2-[(...)
Affinity DataIC50:  93nMAssay Description:For the SARS-CoV 3CLpro assay, 2 μL of 0.02 μM recombinant SARS-CoV 3CL protease were mixed with serial dilutions of each compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed