Found 12 Enz. Inhib. hit(s) with Target = 'Serine-protein kinase ATM' and Ligand = 'BDBM50208517' TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
3D Structure (crystal)TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: <2nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of ATM kinaseMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human ATM using p53 as substrate preincubated for 10 mins by ELISAMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of ATM (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human HeLa nuclear extract derived ATM using glutathioneS-transferase-p53N66 as substrate preincubated for 10 mins followed by ATP addi...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of ATM isolated from human HeLa cell extract using glutathione S-transferase-p53N66 as substrate by ELISAMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Competitive inhibition of ATM (unknown origin) measured by ATP-competitive binding assayMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of ATM in human U2OS cells assessed as inhibition of p53 phosphorylation at Ser15 residueMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of ATM kinase in human MCF7 cells after 1 hr by immunofluorescence assayMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
