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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2 (SGLT2)' and Ligand = 'BDBM50353871'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353871
PNG
(CHEMBL1830345 | US9006187, 10)
Show SMILES COCCOc1ccc(Cc2cc(sc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H25ClO7S/c1-26-6-7-27-13-4-2-11(3-5-13)8-12-9-15(29-20(12)21)19-18(25)17(24)16(23)14(10-22)28-19/h2-5,9,14,16-19,22-25H,6-8,10H2,1H3/t14-,16-,17+,18-,19+/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 115n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353871
PNG
(CHEMBL1830345 | US9006187, 10)
Show SMILES COCCOc1ccc(Cc2cc(sc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H25ClO7S/c1-26-6-7-27-13-4-2-11(3-5-13)8-12-9-15(29-20(12)21)19-18(25)17(24)16(23)14(10-22)28-19/h2-5,9,14,16-19,22-25H,6-8,10H2,1H3/t14-,16-,17+,18-,19+/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 115n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair