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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2 (SGLT2)' and Ligand = 'BDBM50353874'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353874
PNG
(CHEMBL1830348 | US9006187, 7)
Show SMILES CCSc1ccc(Cc2cc(sc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C19H23ClO5S2/c1-2-26-12-5-3-10(4-6-12)7-11-8-14(27-19(11)20)18-17(24)16(23)15(22)13(9-21)25-18/h3-6,8,13,15-18,21-24H,2,7,9H2,1H3/t13-,15-,16+,17-,18+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 48.4n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353874
PNG
(CHEMBL1830348 | US9006187, 7)
Show SMILES CCSc1ccc(Cc2cc(sc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C19H23ClO5S2/c1-2-26-12-5-3-10(4-6-12)7-11-8-14(27-19(11)20)18-17(24)16(23)15(22)13(9-21)25-18/h3-6,8,13,15-18,21-24H,2,7,9H2,1H3/t13-,15-,16+,17-,18+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 48.4n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair