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Found 6 Enz. Inhib. hit(s) with Target = 'Sodium-dependent serotonin transporter' and Ligand = 'BDBM22396'
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  135nMAssay Description:Binding affinity on dopamine and serotonin transporters in striated membranes using [3H]- paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  186nMAssay Description:Binding affinity for Serotonin transporter was determined by [3H]5-HT (serotonin) uptake by striated synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  1.90E+3nM ΔG°:  -32.7kJ/molepH: 7.4 T: 2°CAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataKi:  1.96E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataIC50:  204nMAssay Description:Inhibitory activity against Serotonin transporter was determined for [3H]5-HT (serotonin) uptake by striated synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)
Affinity DataIC50:  2.71E+3nMAssay Description:Inhibitory activity on dopamine and serotonin transporters in striated membranes using [3H]- paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed