Found 46 Enz. Inhib. hit(s) with Target = 'Sodium-dependent serotonin transporter' and Ligand = 'BDBM50010859' TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
3D Structure (crystal)TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 0.770nMAssay Description:Displacement of [3H]imipramine from human 5HT transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 1nMAssay Description:Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK-293 cell membranes after 30 mins by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 2nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]imipramine from human SERT expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]imipramine from human recombinant SERT expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK293 cells membranes incubated for 30 mins by microbeta scintillation...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 5nMAssay Description:Binding affinity towards Serotonin transporter using [3H]-paroxetine as radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(MOUSE)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Binding affinity to Serotonin transporter using [3H]-paroxetine as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 5.70nMAssay Description:Inhibition of human SERT I179C mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 7.57nMAssay Description:Inhibition of [3H]serotonin reuptake at serotonin transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 20nMAssay Description:Displacement of [3H]citalopram from serotonin transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 20nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
Affinity DataKi: 29nMAssay Description:Displacement of [3H]-citalopram from SERT in rat cortex tissue measured after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
Affinity DataKi: 29nMAssay Description:Displacement of [3H]-citalopram from SERT in rat cortex tissue incubated for 60 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 31nMAssay Description:Inhibition of wild-type human SERT expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5HT ...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
Affinity DataKi: 42nMAssay Description:Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
Affinity DataKi: 42nMAssay Description:Inhibition of serotonin (5-HT) uptake into rat brain synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataKi: 1.30E+3nMAssay Description:Inhibition of human SERT I172M mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 0.880nMAssay Description:Displacement of [3H]imipramine from human recombinant 5-HT transporter expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 0.880nMAssay Description:Displacement of [3H]imipramine from human recombinant 5HT transporter expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human SERT W103A mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 4.10nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
Affinity DataIC50: 4.40nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human SERT expressed in CHO cell membranes assessed as reduction in [3H]serotonin uptake preincubated for 10 mins followed by [3H]serot...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 6.80nMAssay Description:Displacement of [3H]imipramin from human recombinant SERT over-expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human 5-HT transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 29nMAssay Description:Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation
Curated by PDSP Ki Database
Janssen Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 29nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
Affinity DataIC50: 61nMAssay Description:Inhibition of SERT expressed in rat brain synaptosomes assessed as decrease in incorporation of [3H]serotonin measured after 15 mins by scintillation...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
Affinity DataIC50: 120nMAssay Description:Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of accumulation of [14C]-5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
Affinity DataIC50: 810nMAssay Description:Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, using [3H]5-HTMore data for this Ligand-Target Pair
