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Found 4 Enz. Inhib. hit(s) with Target = 'Toll-like receptor 7' and Ligand = 'BDBM50189283'
TargetToll-like receptor 7(Homo sapiens (Human))
Genomics Institute Of Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50189283(CHEMBL3828542 | US9597326, Compound 6)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Genomics Institute Of Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50189283(CHEMBL3828542 | US9597326, Compound 6)
Affinity DataEC50:  1.64E+3nMAssay Description:Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Genomics Institute Of Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50189283(CHEMBL3828542 | US9597326, Compound 6)
Affinity DataEC50:  980nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of IL-6 secretion in supernatant after 18 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Mus musculus)
Genomics Institute Of Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50189283(CHEMBL3828542 | US9597326, Compound 6)
Affinity DataEC50:  810nMAssay Description:Agonist activity at TLR7 in Balb/c mouse splenocytes assessed as induction of IL-6 secretion in supernatant after 18 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed