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Found 14 Enz. Inhib. hit(s) with Target = 'Toll-like receptor 7' and Ligand = 'BDBM50241029'
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  760nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells, respectively, (Invivogen, San Diego, Calif., USA) transfected with a SEAP repo...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  260nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assayMore data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  1.34E+3nMAssay Description:Agonist activity at human TLR7 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  420nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) r...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  420nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) r...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  75nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells incubated for 6 to 16 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  250nMAssay Description:Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP r...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  420nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  750nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  330nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  1.26E+3nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of IN-12 stimulationMore data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  420nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair