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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Toll-like receptor 7' and Ligand = 'BDBM507033'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))
BDBM507033
PNG
(US11046671, VTX-135)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1cncnc1
Show InChI InChI=1S/C21H25N5O/c1-3-7-26(8-4-2)21(27)17-9-16-6-5-15(18-12-23-14-24-13-18)10-19(16)25-20(22)11-17/h5-6,9-10,12-14H,3-4,7-8,11H2,1-2H3,(H2,22,25)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.61E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US11046671 (2021)

More data for this
Ligand-Target Pair