Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Toll-like receptor 8' and Ligand = 'BDBM507042'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507042 (2-Amino-N-(cyclopropylmethyl)-8-(1,4-dihydroquinaz...) Show SMILES CCCN(CC1CC1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccccc2N1 Show InChI InChI=1S/C26H29N5O/c1-2-11-31(16-17-7-8-17)26(32)21-12-18-9-10-19(13-23(18)29-24(27)14-21)25-28-15-20-5-3-4-6-22(20)30-25/h3-6,9-10,12-13,17H,2,7-8,11,14-16H2,1H3,(H2,27,29)(H,28,30)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
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