BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Toll-like receptor 8' and Ligand = 'BDBM507044'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 8


(Homo sapiens (Human))
BDBM507044
PNG
(2-Amino-8-(5-chloro-1,4-dihydroquinazolin-2-yl)-N,...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2c(C)cccc2N1
Show InChI InChI=1S/C26H31N5O/c1-4-11-31(12-5-2)26(32)20-13-18-9-10-19(14-23(18)29-24(27)15-20)25-28-16-21-17(3)7-6-8-22(21)30-25/h6-10,13-14H,4-5,11-12,15-16H2,1-3H3,(H2,27,29)(H,28,30)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US11046671 (2021)

More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM507044
PNG
(2-Amino-8-(5-chloro-1,4-dihydroquinazolin-2-yl)-N,...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2c(C)cccc2N1
Show InChI InChI=1S/C26H31N5O/c1-4-11-31(12-5-2)26(32)20-13-18-9-10-19(14-23(18)29-24(27)15-20)25-28-16-21-17(3)7-6-8-22(21)30-25/h6-10,13-14H,4-5,11-12,15-16H2,1-3H3,(H2,27,29)(H,28,30)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 11n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US11046671 (2021)

More data for this
Ligand-Target Pair