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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Toll-like receptor 8' and Ligand = 'BDBM507045'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 8


(Homo sapiens (Human))
BDBM507045
PNG
(2-Amino-8-(7-chloro-1,4-dihydroquinazolin-2-yl)-N,...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccc(Cl)cc2N1
Show InChI InChI=1S/C25H28ClN5O/c1-3-9-31(10-4-2)25(32)19-11-16-5-6-17(12-21(16)29-23(27)13-19)24-28-15-18-7-8-20(26)14-22(18)30-24/h5-8,11-12,14H,3-4,9-10,13,15H2,1-2H3,(H2,27,29)(H,28,30)
PDB

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UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 9n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US11046671 (2021)

More data for this
Ligand-Target Pair