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Found 2 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM112546'
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM112546(US8618103, I-42)
Affinity DataKi:  0.000748nM IC50:  0.00149nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM112546(US8618103, I-42)
Affinity DataIC50:  1nMAssay Description:Inhibition of JAK3 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed