BindingDB PrimarySearch

Found 65 Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2' and Ligand = 'BDBM4814'

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

Ki: 2.90nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 10 mins by Global fit analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

Ki: 9nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

Ki: 9nMAssay Description:Competitive inhibition of VEGFR2 by qPCR methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

Ki: 9nMAssay Description:Competitive inhibition of recombinant GST-tagged VEGFR2 cytoplasmic domain in presence of ATPMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

Ki: 9nMAssay Description:Binding affinity to VEGFR2 (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 0.400nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 4.70nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged KDR (790 to end residues) expressed in baculovirus infected Sf21 insect cells after 60 mins by...More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 5.5nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 5.70nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 in presence of ATP measured without preincubation by AlphaScreen analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 7.40nMAssay Description:The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 8nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 9nMAssay Description:Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 10nMAssay Description:The effects of compound of formula II on inhibiting VEGFR were compared against that of sunitinib in vitro.More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 12nMAssay Description:Inhibition of human VEGFR2 preincubated for 10 mins before ATP addition measured after 45 minsMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 13nMpH: 7.4Assay Description:The substrate of poly (Glu, Tyr) 4:1 (20 lg/mL) (Sigma, St. Louis, MO, USA) was precoated in 96-well ELISA plates, and the kinase was incubated with ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 15nMAssay Description:Inhibition of human VEGFR2 after 30 mins by ELISAMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 18nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 18nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged VEGFR-2 (unknown origin) using FL-Peptide 22 as substrate after 90 mins by mobility shift assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 18nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 19nMAssay Description:Inhibition of VEGFR2 in human U251 cells compound pretreated for 60 min before VEGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 19nMAssay Description:Inhibition of VEGFR2 in human U251 cells preincubated for 60 mins followed by VEGF stimulation and measured after 10 mins by ELISAMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 19nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISAMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 19nMAssay Description:Inhibition of VEGF-induced VEGFR2 activation in human U251 cells pretreated for 60 mins followed by VEGF addition and measured after 10 mins by ELISAMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 19nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 19nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISA assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 23nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 27nMAssay Description:Inhibition of KDR by cellular assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 29nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly (Glu, Tyr) 4:1 as substrate preincubated with substrate followed by enzyme challenge for 1 hr by ELI...More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 31nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 37nMAssay Description:Inhibition of N-terminal GST-tagged KDR after 4 hrs by luciferase-luciferin coupled chemiluminescence assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 38nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 39nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 40nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ATP/substrate peptide after 1 hr by colorimetric ELISAMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 53nMAssay Description:Inhibition of KDR autophosphorylation in HUVEC by Western blot analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 54nMAssay Description:Inhibition of VEGFR2 (unknown origin) using TK substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 65nMAssay Description:Inhibition of recombinant human His-tagged VEGFR2 cytoplasmic domain (789 to 1356 residues) expressed in baculovirus expression system measured after...More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 70nMAssay Description:Inhibition of recombinant VEGFR2 using poly(Glu,Tyr)4 as substrate assessed as inhibition of [33P]Phosphate incorporation into substrate after 80 min...More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 75nMAssay Description:Inhibition of VEGFR2 (unknown origin) by Kinase-Glo max reagent-based assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 76nMAssay Description:Inhibition of VEGFR2 (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 80nMpH: 7.5 T: 2°CAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 80nMAssay Description:Inhibition of VEGFR2 (unknown origin) phosphorylationMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 80nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 80nMAssay Description:Inhibition of VGFR-2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 80nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 80nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 98nMAssay Description:Inhibition of human N-terminal His-tagged phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 139nMAssay Description:Inhibition of VEGFR2-induced cell proliferation in HUVEC after 72 hrs by sulforhodamine B methodMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 140nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic VEGFR2 (789 to 1356 residues) expressed in baculovirus expression system incubated for 1 hr by...More data for this Ligand-Target Pair

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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 147nMAssay Description:Inhibition of human N-terminal His-tagged phosphorylated VEGFR2 in presence of ATP measured without preincubation by AlphaScreen analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 185nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Displayed 1 to 50 (of 65 total ) | Next | Last >>

Filter my 65 hits

Targets 1▿
- Vascular endothelial growth factor receptor 2 65
Publications 50▿
- Bioorg Med Chem 19: 5342-51 (2011) 5
- J Med Chem 53: 8140-9 (2010) 2
- Proc Natl Acad Sci U S A 104: 19936-41 (2007) 2
- Eur J Med Chem 161: 445-455 (2019) 1
- Eur J Med Chem 82: 139-51 (2014) 1
- Eur J Med Chem 45: 5420-7 (2010) 1
- Bioorg Med Chem Lett 22: 4979-85 (2012) 1
- Eur J Med Chem 103: 105-22 (2015) 1
- Bioorg Med Chem 20: 4217-25 (2012) 1
- Eur J Med Chem 84: 698-707 (2014) 1
- Bioorg Med Chem 25: 545-556 (2017) 1
- Nat Biotechnol 23: 329-36 (2005) 1
- Nat Biotechnol 29: 1046-51 (2011) 1
- PubChem Bioassay (2008) 1
- Bioorg Med Chem 22: 3753-72 (2014) 1
- Eur J Med Chem 179: 147-165 (2019) 1
- Bioorg Med Chem 21: 1857-64 (2013) 1
- Bioorg Med Chem 35: (2021) 1
- Eur J Med Chem 208: (2020) 1
- US Patent US10464902 (2019) 1
- J Med Chem 60: 248-262 (2017) 1
- J Med Chem 55: 725-34 (2012) 1
- Bioorg Med Chem 18: 5261-73 (2010) 1
- Eur J Med Chem 72: 146-59 (2014) 1
- Eur J Med Chem 150: 783-795 (2018) 1
- Eur J Med Chem 108: 495-504 (2016) 1
- Eur J Med Chem 168: 315-329 (2019) 1
- Eur J Med Chem 211: (2021) 1
- J Med Chem 46: 1116-9 (2003) 1
- J Med Chem 64: 4870-4890 (2021) 1
- ACS Med Chem Lett 5: 480-4 (2014) 1
- Bioorg Med Chem 21: 1312-23 (2013) 1
- Eur J Med Chem 58: 272-80 (2012) 1
- Nat Biotechnol 26: 127-32 (2008) 1
- Bioorg Med Chem Lett 20: 6129-32 (2010) 1
- Eur J Med Chem 53: 254-63 (2012) 1
- US Patent US9914707 (2018) 1
- Eur J Med Chem 46: 5970-7 (2011) 1
- Bioorg Med Chem Lett 28: 3085-3093 (2018) 1
- J Med Chem 61: 140-157 (2018) 1
- Eur J Med Chem 118: 328-39 (2016) 1
- Bioorg Med Chem Lett 19: 1323-8 (2009) 1
- Bioorg Med Chem Lett 17: 2126-33 (2007) 1
- Bioorg Med Chem 20: 910-4 (2012) 1
- J Med Chem 64: 11747-11773 (2021) 1
- Bioorg Med Chem 18: 4674-86 (2011) 1
- Blood 114: 2984-92 (2009) 1
- US Patent US9163010 (2015) 1
- Eur J Med Chem 197: (2020) 1
- Chem Biol Drug Des 87: 694-703 (2016) 1
- ...
Institutions 33▿
- Duquesne University 10
- Ambit Biosciences 5
- Takeda Pharmaceutical 5
- China Pharmaceutical University 5
- Shanghai Hengrui Pharmaceuticals 2
- Harvard Medical School 2
- Konkuk University 1
- Sugen 1
- University Of Strasburg 1
- Exelixis 1
- University Of Arkansas For Medical Sciences 1
- Universidad De Talca 1
- Shanghai Jiao Tong University 1
- Ontogenesis 1
- Nanjing University Of Chinese Medicine 1
- Methylgene 1
- Beta Pharma 1
- Universit£ 1
- Industrial Technology Research Institute 1
- Zhejiang University 1
- Technische Universit£T Braunschweig 1
- National Taiwan University 1
- East China University Of Science & Technology 1
- Mansoura University 1
- Comenius University 1
- Qilu Pharmaceutical 1
- China Medical University 1
- Shenyang Pharmaceutical University 1
- University Of Kentucky 1
- Shanghai Institute Of Material Medica, Chinese Academy Of Sciences 1
- University Of Colorado Anschutz Medical Campus 1
- Yunnan University 1
- Cairo University 1
- ...
Affinity: 0.20 to 8.3E+4 nM▿
- Ki 5
- IC50 53
- Kd 7
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1