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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4C' and Ligand = 'BDBM50228865'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228865
PNG
(CHEMBL354430)
Show SMILES Cc1ccc(CNC(=O)c2cccnc2Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H17FN2O2/c1-14-4-6-15(7-5-14)13-23-19(24)18-3-2-12-22-20(18)25-17-10-8-16(21)9-11-17/h2-12H,13H2,1H3,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 540n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228865
PNG
(CHEMBL354430)
Show SMILES Cc1ccc(CNC(=O)c2cccnc2Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H17FN2O2/c1-14-4-6-15(7-5-14)13-23-19(24)18-3-2-12-22-20(18)25-17-10-8-16(21)9-11-17/h2-12H,13H2,1H3,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair