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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4C' and Ligand = 'BDBM50228868'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228868
PNG
(CHEMBL168121)
Show SMILES FC(F)(F)c1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C20H15F3N2O2/c21-20(22,23)15-8-4-9-16(12-15)27-19-17(10-5-11-24-19)18(26)25-13-14-6-2-1-3-7-14/h1-12H,13H2,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.50E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228868
PNG
(CHEMBL168121)
Show SMILES FC(F)(F)c1cccc(Oc2ncccc2C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C20H15F3N2O2/c21-20(22,23)15-8-4-9-16(12-15)27-19-17(10-5-11-24-19)18(26)25-13-14-6-2-1-3-7-14/h1-12H,13H2,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.40E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
More data for this
Ligand-Target Pair