BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)' and Monomerid = 19275   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19275
PNG
(9-oxo-N-[2-(pyridin-3-yl)propan-2-yl]-9,10-dihydro...)
Show SMILES CC(C)(NC(=O)c1ccc2c(c1)[nH]c1ccccc1c2=O)c1cccnc1
Show InChI InChI=1S/C22H19N3O2/c1-22(2,15-6-5-11-23-13-15)25-21(27)14-9-10-17-19(12-14)24-18-8-4-3-7-16(18)20(17)26/h3-13H,1-2H3,(H,24,26)(H,25,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 42n/a 2.20E+3n/an/a8.025



Bristol-Myers Squibb Co.



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair