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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)' and Monomerid = 19286   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19286
PNG
(2-fluoro-N-[2-(6-methylpyridin-3-yl)propan-2-yl]-9...)
Show SMILES Cc1ccc(cn1)C(C)(C)NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F
Show InChI InChI=1S/C23H20FN3O2/c1-13-8-9-14(12-25-13)23(2,3)27-22(29)16-11-20-17(10-18(16)24)21(28)15-6-4-5-7-19(15)26-20/h4-12H,1-3H3,(H,26,28)(H,27,29)
PDB
MMDB

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Similars

Article
PubMed
n/an/a 23n/a 750n/an/a8.025



Bristol-Myers Squibb Co.



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair