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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)' and Monomerid = 19288   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19288
PNG
(Acridone-Based Inhibitor, 4l | N-{2-[2-(dimethylam...)
Show SMILES CN(C)c1cc(ccn1)C(C)(C)NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F
Show InChI InChI=1S/C24H23FN4O2/c1-24(2,14-9-10-26-21(11-14)29(3)4)28-23(31)16-13-20-17(12-18(16)25)22(30)15-7-5-6-8-19(15)27-20/h5-13H,1-4H3,(H,27,30)(H,28,31)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/a 640n/an/a8.025



Bristol-Myers Squibb Co.



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair