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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)' and Monomerid = 50133715   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50133715
PNG
(1-(3-Cyano-1-methyl-1H-indol-6-yl)-3-m-tolyl-urea ...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc3c(cn(C)c3c2)C#N)c1
Show InChI InChI=1S/C18H16N4O/c1-12-4-3-5-14(8-12)20-18(23)21-15-6-7-16-13(10-19)11-22(2)17(16)9-15/h3-9,11H,1-2H3,(H2,20,21,23)
PDB
MMDB

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Article
PubMed
n/an/a 670n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme


Bioorg Med Chem Lett 13: 3557-60 (2003)


Article DOI: 10.1016/s0960-894x(03)00757-1
BindingDB Entry DOI: 10.7270/Q2J67G94
More data for this
Ligand-Target Pair