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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)' and Monomerid = 50133717   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50133717
PNG
(CHEMBL118384 | {2-[2-(3-Cyano-1-methyl-1H-indol-6-...)
Show SMILES Cn1cc(C#N)c2ccc(Nc3ncc(o3)-c3ccccc3CNC(=O)OC3CCOC3)cc12
Show InChI InChI=1S/C25H23N5O4/c1-30-14-17(11-26)20-7-6-18(10-22(20)30)29-24-27-13-23(34-24)21-5-3-2-4-16(21)12-28-25(31)33-19-8-9-32-15-19/h2-7,10,13-14,19H,8-9,12,15H2,1H3,(H,27,29)(H,28,31)
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Article
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n/an/a 420n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme


Bioorg Med Chem Lett 13: 3557-60 (2003)


Article DOI: 10.1016/s0960-894x(03)00757-1
BindingDB Entry DOI: 10.7270/Q2J67G94
More data for this
Ligand-Target Pair