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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)' and Monomerid = 50133718   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50133718
PNG
(CHEMBL119655 | N-{4-[2-(3-Cyano-1-methyl-1H-indol-...)
Show SMILES Cn1cc(C#N)c2ccc(Nc3ncc(o3)-c3ccc(CNC(=O)c4ccccc4)cc3)cc12
Show InChI InChI=1S/C27H21N5O2/c1-32-17-21(14-28)23-12-11-22(13-24(23)32)31-27-30-16-25(34-27)19-9-7-18(8-10-19)15-29-26(33)20-5-3-2-4-6-20/h2-13,16-17H,15H2,1H3,(H,29,33)(H,30,31)
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MMDB

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Article
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme


Bioorg Med Chem Lett 13: 3557-60 (2003)


Article DOI: 10.1016/s0960-894x(03)00757-1
BindingDB Entry DOI: 10.7270/Q2J67G94
More data for this
Ligand-Target Pair