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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)' and Monomerid = 50133722   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50133722
PNG
(CHEMBL118983 | {2-[2-(3-Cyano-1-methyl-1H-indol-6-...)
Show SMILES Cn1cc(C#N)c2ccc(Nc3ncc(o3)-c3ccccc3CNC(=O)OCCC#N)cc12
Show InChI InChI=1S/C24H20N6O3/c1-30-15-17(12-26)19-8-7-18(11-21(19)30)29-23-27-14-22(33-23)20-6-3-2-5-16(20)13-28-24(31)32-10-4-9-25/h2-3,5-8,11,14-15H,4,10,13H2,1H3,(H,27,29)(H,28,31)
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Article
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n/an/a 420n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme


Bioorg Med Chem Lett 13: 3557-60 (2003)


Article DOI: 10.1016/s0960-894x(03)00757-1
BindingDB Entry DOI: 10.7270/Q2J67G94
More data for this
Ligand-Target Pair