TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of 5-LO in fMLP-stimulated human monocytes assessed as reduction in HETE formationMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of 5-LO in LPS-stimulated human neutrophils assessed as reduction in HETE formationMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 1.40E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 7.50E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 530nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 8.50E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 290nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 8.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 1.50E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 1.80E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 230nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 1.60E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 900nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 1.40E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 240nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 1.08E+3nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 2.20E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 120nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 7.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 5.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 250nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 1.00E+3nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 110nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 240nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 1.44E+3nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 270nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 5.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataKd: 690nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataEC50: 6.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair