Compile Data Set for Download or QSAR
maximum 50k data
Found 52 from Friedrich-Schiller-University
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50:  500nMAssay Description:Inhibition of 5-LO in fMLP-stimulated human monocytes assessed as reduction in HETE formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of 5-LO in LPS-stimulated human neutrophils assessed as reduction in HETE formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012187(INDIRUBIN 2)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012185(CHEMBL3265230)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012187(INDIRUBIN 2)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012186(CHEMBL3265231)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012186(CHEMBL3265231)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012185(CHEMBL3265230)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012185(CHEMBL3265230)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012186(CHEMBL3265231)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012187(INDIRUBIN 2)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50:  1.11E+4nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162442(CHEMBL386749 | H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Phe-...)
Affinity DataEC50:  1.40E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162439(CHEMBL439086 | H-Glu-Gly-Leu-Asn-pTyr-Hfe-Val-Leu-...)
Affinity DataEC50:  7.50E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162449(CHEMBL269042 | H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Phe-...)
Affinity DataKd:  530nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162448(CHEMBL413492 | H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Ser(...)
Affinity DataEC50:  8.50E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162448(CHEMBL413492 | H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Ser(...)
Affinity DataKd:  290nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162443(CHEMBL412186 | H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Abu(...)
Affinity DataEC50:  8.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162449(CHEMBL269042 | H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Phe-...)
Affinity DataEC50:  1.50E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162447(CHEMBL412918 | H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Abu(...)
Affinity DataEC50:  1.80E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162436((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{2-[(S)-2-((S)-2-Ami...)
Affinity DataKd:  230nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162440(CHEMBL371014 | H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Leu-...)
Affinity DataEC50:  1.60E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162446((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{2-[(S)-2-((S)-2-Ami...)
Affinity DataKd:  900nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162446((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{2-[(S)-2-((S)-2-Ami...)
Affinity DataEC50:  1.40E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162438((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{(S)-2-[(S)-2-((S)-2...)
Affinity DataKd:  240nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162445(CHEMBL386769 | H-Glu-Gly-Leu-Asn-pTyr-Ser(betaPh)-...)
Affinity DataKd:  1.08E+3nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162445(CHEMBL386769 | H-Glu-Gly-Leu-Asn-pTyr-Ser(betaPh)-...)
Affinity DataEC50:  2.20E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162435(CHEMBL274087 | H-Glu-Gly-Leu-Asn-pTyr-Nle-Val-Phe-...)
Affinity DataKd:  120nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162444(CHEMBL273780 | H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Leu-...)
Affinity DataEC50:  7.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162438((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{(S)-2-[(S)-2-((S)-2...)
Affinity DataEC50:  5.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162443(CHEMBL412186 | H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Abu(...)
Affinity DataKd:  250nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162442(CHEMBL386749 | H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Phe-...)
Affinity DataKd:  1.00E+3nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162441((4S)-4-amino-4-[({[(1S)-1-{[(7R,10R,13S,16S)-7-{[(...)
Affinity DataKd:  110nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162438((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{(S)-2-[(S)-2-((S)-2...)
Affinity DataKd:  240nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162440(CHEMBL371014 | H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Leu-...)
Affinity DataKd:  1.44E+3nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162439(CHEMBL439086 | H-Glu-Gly-Leu-Asn-pTyr-Hfe-Val-Leu-...)
Affinity DataKd:  270nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162438((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{(S)-2-[(S)-2-((S)-2...)
Affinity DataEC50:  5.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162444(CHEMBL273780 | H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Leu-...)
Affinity DataKd:  690nMAssay Description:Dissociation constant for the interaction of the compound with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162436((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{2-[(S)-2-((S)-2-Ami...)
Affinity DataEC50:  6.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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