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Compile Data Set for Download or QSAR

Found 93 hits with Last Name = 'fine' and Initial = 'rm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50355501
PNG
(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Show SMILES N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/s2
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n/an/a 3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50355501
PNG
(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Show SMILES N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/s2
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n/an/a 3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50332294
PNG
(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Show SMILES Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)
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n/an/a 3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50355501
PNG
(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Show SMILES N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/s2
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n/an/a 19n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TYK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50332296
PNG
(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Show SMILES Nc1nc(Nc2cccc(c2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H12F2N6O3S/c16-10-5-2-6-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-3-1-4-9(7-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
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n/an/a 19n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50332302
PNG
((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Show SMILES CN(C)c1cccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)c1
Show InChI InChI=1S/C17H16F2N6O/c1-24(2)11-6-3-5-10(9-11)21-17-22-16(20)25(23-17)15(26)14-12(18)7-4-8-13(14)19/h3-9H,1-2H3,(H3,20,21,22,23)
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n/an/a 39n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25082
PNG
(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)
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n/an/a 39.9n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50332300
PNG
(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Show SMILES Nc1nc(Nc2ccc(cc2)C(O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C16H11F2N5O3/c17-10-2-1-3-11(18)12(10)13(24)23-15(19)21-16(22-23)20-9-6-4-8(5-7-9)14(25)26/h1-7H,(H,25,26)(H3,19,20,21,22)
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n/an/a 42n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TYK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50332300
PNG
(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Show SMILES Nc1nc(Nc2ccc(cc2)C(O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C16H11F2N5O3/c17-10-2-1-3-11(18)12(10)13(24)23-15(19)21-16(22-23)20-9-6-4-8(5-7-9)14(25)26/h1-7H,(H,25,26)(H3,19,20,21,22)
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n/an/a 45n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50332303
PNG
((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Show SMILES CN(C)c1ccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C17H16F2N6O/c1-24(2)11-8-6-10(7-9-11)21-17-22-16(20)25(23-17)15(26)14-12(18)4-3-5-13(14)19/h3-9H,1-2H3,(H3,20,21,22,23)
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n/an/a 70n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TYK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50332302
PNG
((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Show SMILES CN(C)c1cccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)c1
Show InChI InChI=1S/C17H16F2N6O/c1-24(2)11-6-3-5-10(9-11)21-17-22-16(20)25(23-17)15(26)14-12(18)7-4-8-13(14)19/h3-9H,1-2H3,(H3,20,21,22,23)
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n/an/a 70n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TYK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50332296
PNG
(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Show SMILES Nc1nc(Nc2cccc(c2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H12F2N6O3S/c16-10-5-2-6-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-3-1-4-9(7-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
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SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TYK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50332303
PNG
((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Show SMILES CN(C)c1ccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C17H16F2N6O/c1-24(2)11-8-6-10(7-9-11)21-17-22-16(20)25(23-17)15(26)14-12(18)4-3-5-13(14)19/h3-9H,1-2H3,(H3,20,21,22,23)
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n/an/a 80n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25084
PNG
(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Show SMILES Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
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n/an/a 83n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50332294
PNG
(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Show SMILES Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)
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Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50332294
PNG
(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Show SMILES Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)
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Curated by ChEMBL


Assay Description
Inhibition of human recombinant TYK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50332304
PNG
((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Show SMILES Nc1nc(Nc2cccnc2)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C14H10F2N6O/c15-9-4-1-5-10(16)11(9)12(23)22-13(17)20-14(21-22)19-8-3-2-6-18-7-8/h1-7H,(H3,17,19,20,21)
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n/an/a 160n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25095
PNG
(4-(2,4-diaminopteridin-6-yl)benzene-1,2-diol | dia...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C12H10N6O2/c13-10-9-11(18-12(14)17-10)15-4-6(16-9)5-1-2-7(19)8(20)3-5/h1-4,19-20H,(H4,13,14,15,17,18)
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n/an/a 195n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50332301
PNG
((5-amino-3-(phenylamino)-1H-1,2,4-triazol-1-yl)(2,...)
Show SMILES Nc1nc(Nc2ccccc2)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H11F2N5O/c16-10-7-4-8-11(17)12(10)13(23)22-14(18)20-15(21-22)19-9-5-2-1-3-6-9/h1-8H,(H3,18,19,20,21)
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n/an/a 230n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), delta


(Homo sapiens (Human))
BDBM25084
PNG
(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Show SMILES Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
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n/an/a 235n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25094
PNG
(4-[2,4-diamino-7-(3,4-dihydroxyphenyl)pteridin-6-y...)
Show SMILES Nc1nc(N)c2nc(-c3ccc(O)c(O)c3)c(nc2n1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C18H14N6O4/c19-16-15-17(24-18(20)23-16)22-14(8-2-4-10(26)12(28)6-8)13(21-15)7-1-3-9(25)11(27)5-7/h1-6,25-28H,(H4,19,20,22,23,24)
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n/an/a 273n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50332304
PNG
((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Show SMILES Nc1nc(Nc2cccnc2)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C14H10F2N6O/c15-9-4-1-5-10(16)11(9)12(23)22-13(17)20-14(21-22)19-8-3-2-6-18-7-8/h1-7H,(H3,17,19,20,21)
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n/an/a 300n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TYK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50332301
PNG
((5-amino-3-(phenylamino)-1H-1,2,4-triazol-1-yl)(2,...)
Show SMILES Nc1nc(Nc2ccccc2)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H11F2N5O/c16-10-7-4-8-11(17)12(10)13(23)22-14(18)20-15(21-22)19-9-5-2-1-3-6-9/h1-8H,(H3,18,19,20,21)
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n/an/a 360n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TYK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50355501
PNG
(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Show SMILES N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/s2
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n/an/a 430n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK3 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50332299
PNG
(CHEMBL1287940 | methyl 4-(5-amino-1-(2,6-difluorob...)
Show SMILES COC(=O)c1ccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C17H13F2N5O3/c1-27-15(26)9-5-7-10(8-6-9)21-17-22-16(20)24(23-17)14(25)13-11(18)3-2-4-12(13)19/h2-8H,1H3,(H3,20,21,22,23)
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n/an/a 500n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50332298
PNG
(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Show SMILES Nc1nc(Nc2cccc(c2)C(O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C16H11F2N5O3/c17-10-5-2-6-11(18)12(10)13(24)23-15(19)21-16(22-23)20-9-4-1-3-8(7-9)14(25)26/h1-7H,(H,25,26)(H3,19,20,21,22)
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n/an/a 610n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50332298
PNG
(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Show SMILES Nc1nc(Nc2cccc(c2)C(O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C16H11F2N5O3/c17-10-5-2-6-11(18)12(10)13(24)23-15(19)21-16(22-23)20-9-4-1-3-8(7-9)14(25)26/h1-7H,(H,25,26)(H3,19,20,21,22)
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n/an/a 690n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TYK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50332299
PNG
(CHEMBL1287940 | methyl 4-(5-amino-1-(2,6-difluorob...)
Show SMILES COC(=O)c1ccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C17H13F2N5O3/c1-27-15(26)9-5-7-10(8-6-9)21-17-22-16(20)24(23-17)14(25)13-11(18)3-2-4-12(13)19/h2-8H,1H3,(H3,20,21,22,23)
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n/an/a 760n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TYK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50332303
PNG
((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Show SMILES CN(C)c1ccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C17H16F2N6O/c1-24(2)11-8-6-10(7-9-11)21-17-22-16(20)25(23-17)15(26)14-12(18)4-3-5-13(14)19/h3-9H,1-2H3,(H3,20,21,22,23)
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n/an/a 850n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK3 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25106
PNG
(4-[4-amino-6-(3,4-dihydroxyphenyl)pteridin-7-yl]be...)
Show SMILES Nc1ncnc2nc(-c3ccc(O)c(O)c3)c(nc12)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C18H13N5O4/c19-17-16-18(21-7-20-17)23-15(9-2-4-11(25)13(27)6-9)14(22-16)8-1-3-10(24)12(26)5-8/h1-7,24-27H,(H2,19,20,21,23)
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n/an/a 968n/an/an/an/an/an/a



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50332297
PNG
(CHEMBL1287812 | ethyl 3-(5-amino-1-(2,6-difluorobe...)
Show SMILES CCOC(=O)c1cccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)c1
Show InChI InChI=1S/C18H15F2N5O3/c1-2-28-16(27)10-5-3-6-11(9-10)22-18-23-17(21)25(24-18)15(26)14-12(19)7-4-8-13(14)20/h3-9H,2H2,1H3,(H3,21,22,23,24)
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n/an/a 990n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50332294
PNG
(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Show SMILES Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)
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n/an/a 1.00E+3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK3 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25096
PNG
(4-(2,4-diaminopteridin-6-yl)phenol | diaminopterid...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1ccc(O)cc1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-1-3-7(19)4-2-6/h1-5,19H,(H4,13,14,15,17,18)
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n/an/a 1.20E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
p110β/p85α


(Homo sapiens (Human))
BDBM25084
PNG
(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Show SMILES Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
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n/an/a 1.20E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50332296
PNG
(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Show SMILES Nc1nc(Nc2cccc(c2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H12F2N6O3S/c16-10-5-2-6-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-3-1-4-9(7-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
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n/an/a 1.25E+3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK3 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (Human))
BDBM25084
PNG
(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Show SMILES Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
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n/an/a 1.30E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25112
PNG
(4-(4-aminopteridin-6-yl)benzene-1,2-diol | aminopt...)
Show SMILES Nc1ncnc2ncc(nc12)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C12H9N5O2/c13-11-10-12(16-5-15-11)14-4-7(17-10)6-1-2-8(18)9(19)3-6/h1-5,18-19H,(H2,13,14,15,16)
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n/an/a 1.30E+3n/an/an/an/an/an/a



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50332300
PNG
(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Show SMILES Nc1nc(Nc2ccc(cc2)C(O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C16H11F2N5O3/c17-10-2-1-3-11(18)12(10)13(24)23-15(19)21-16(22-23)20-9-6-4-8(5-7-9)14(25)26/h1-7H,(H,25,26)(H3,19,20,21,22)
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n/an/a 1.47E+3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK3 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50332297
PNG
(CHEMBL1287812 | ethyl 3-(5-amino-1-(2,6-difluorobe...)
Show SMILES CCOC(=O)c1cccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)c1
Show InChI InChI=1S/C18H15F2N5O3/c1-2-28-16(27)10-5-3-6-11(9-10)22-18-23-17(21)25(24-18)15(26)14-12(19)7-4-8-13(14)20/h3-9H,2H2,1H3,(H3,21,22,23,24)
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n/an/a 1.72E+3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TYK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50332302
PNG
((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Show SMILES CN(C)c1cccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)c1
Show InChI InChI=1S/C17H16F2N6O/c1-24(2)11-6-3-5-10(9-11)21-17-22-16(20)25(23-17)15(26)14-12(18)7-4-8-13(14)19/h3-9H,1-2H3,(H3,20,21,22,23)
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n/an/a 2.00E+3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK3 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50332300
PNG
(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Show SMILES Nc1nc(Nc2ccc(cc2)C(O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C16H11F2N5O3/c17-10-2-1-3-11(18)12(10)13(24)23-15(19)21-16(22-23)20-9-6-4-8(5-7-9)14(25)26/h1-7H,(H,25,26)(H3,19,20,21,22)
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n/an/a 2.11E+3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50332296
PNG
(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Show SMILES Nc1nc(Nc2cccc(c2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H12F2N6O3S/c16-10-5-2-6-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-3-1-4-9(7-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
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n/an/a 2.50E+3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50332303
PNG
((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Show SMILES CN(C)c1ccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C17H16F2N6O/c1-24(2)11-8-6-10(7-9-11)21-17-22-16(20)25(23-17)15(26)14-12(18)4-3-5-13(14)19/h3-9H,1-2H3,(H3,20,21,22,23)
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n/an/a 2.50E+3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25097
PNG
(4-[2,4-diamino-7-(4-hydroxyphenyl)pteridin-6-yl]ph...)
Show SMILES Nc1nc(N)c2nc(-c3ccc(O)cc3)c(nc2n1)-c1ccc(O)cc1
Show InChI InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-3-7-12(26)8-4-10)13(21-15)9-1-5-11(25)6-2-9/h1-8,25-26H,(H4,19,20,22,23,24)
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n/an/a 2.70E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25098
PNG
(3-(2,4-diaminopteridin-7-yl)phenol | diaminopterid...)
Show SMILES Nc1nc(N)c2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)16-8(5-15-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,16,17,18)
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n/an/a 3.00E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50332301
PNG
((5-amino-3-(phenylamino)-1H-1,2,4-triazol-1-yl)(2,...)
Show SMILES Nc1nc(Nc2ccccc2)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H11F2N5O/c16-10-7-4-8-11(17)12(10)13(23)22-14(18)20-15(21-22)19-9-5-2-1-3-6-9/h1-8H,(H3,18,19,20,21)
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n/an/a 3.25E+3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK3 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25091
PNG
(3-[4-amino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol...)
Show SMILES Nc1ncnc2nc(-c3cccc(O)c3)c(nc12)-c1cccc(O)c1
Show InChI InChI=1S/C18H13N5O2/c19-17-16-18(21-9-20-17)23-15(11-4-2-6-13(25)8-11)14(22-16)10-3-1-5-12(24)7-10/h1-9,24-25H,(H2,19,20,21,23)
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n/an/a 4.00E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25110
PNG
(4-[4-amino-6-(4-hydroxyphenyl)pteridin-7-yl]phenol...)
Show SMILES Nc1ncnc2nc(-c3ccc(O)cc3)c(nc12)-c1ccc(O)cc1
Show InChI InChI=1S/C18H13N5O2/c19-17-16-18(21-9-20-17)23-15(11-3-7-13(25)8-4-11)14(22-16)10-1-5-12(24)6-2-10/h1-9,24-25H,(H2,19,20,21,23)
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n/an/a 4.00E+3n/an/an/an/an/an/a



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM25099
PNG
(4-(2,4-diaminopteridin-7-yl)phenol | diaminopterid...)
Show SMILES Nc1nc(N)c2ncc(nc2n1)-c1ccc(O)cc1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)16-8(5-15-9)6-1-3-7(19)4-2-6/h1-5,19H,(H4,13,14,16,17,18)
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n/an/a 4.70E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50332302
PNG
((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Show SMILES CN(C)c1cccc(Nc2nc(N)n(n2)C(=O)c2c(F)cccc2F)c1
Show InChI InChI=1S/C17H16F2N6O/c1-24(2)11-6-3-5-10(9-11)21-17-22-16(20)25(23-17)15(26)14-12(18)7-4-8-13(14)19/h3-9H,1-2H3,(H3,20,21,22,23)
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n/an/a 5.00E+3n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK2 by TR-FRET assay


Bioorg Med Chem Lett 20: 7454-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.026
BindingDB Entry DOI: 10.7270/Q22B901J
More data for this
Ligand-Target Pair
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