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Compile Data Set for Download or QSAR

Found 173 hits with Last Name = 'fukuda' and Initial = 't'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50088846
PNG
(CHEMBL353678 | N-{4-[2-(4-Phenyl-piperazin-1-yl)-e...)
Show SMILES CC(=O)NCc1ccc(CCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C21H27N3O/c1-18(25)22-17-20-9-7-19(8-10-20)11-12-23-13-15-24(16-14-23)21-5-3-2-4-6-21/h2-10H,11-17H2,1H3,(H,22,25)
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2.90n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50088844
PNG
(4-{4-[4-(4-Phenyl-piperazin-1-yl)-butyl]-phenyl}-t...)
Show SMILES Nc1nc(cs1)-c1ccc(CCCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H28N4S/c24-23-25-22(18-28-23)20-11-9-19(10-12-20)6-4-5-13-26-14-16-27(17-15-26)21-7-2-1-3-8-21/h1-3,7-12,18H,4-6,13-17H2,(H2,24,25)
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3.80n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50088839
PNG
(CHEMBL169702 | N-{4-[4-(4-Phenyl-piperazin-1-yl)-b...)
Show SMILES CC(=O)NCc1ccc(CCCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H31N3O/c1-20(27)24-19-22-12-10-21(11-13-22)7-5-6-14-25-15-17-26(18-16-25)23-8-3-2-4-9-23/h2-4,8-13H,5-7,14-19H2,1H3,(H,24,27)
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4.60n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of human trypsin.


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50088844
PNG
(4-{4-[4-(4-Phenyl-piperazin-1-yl)-butyl]-phenyl}-t...)
Show SMILES Nc1nc(cs1)-c1ccc(CCCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H28N4S/c24-23-25-22(18-28-23)20-11-9-19(10-12-20)6-4-5-13-26-14-16-27(17-15-26)21-7-2-1-3-8-21/h1-3,7-12,18H,4-6,13-17H2,(H2,24,25)
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5.5n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50088839
PNG
(CHEMBL169702 | N-{4-[4-(4-Phenyl-piperazin-1-yl)-b...)
Show SMILES CC(=O)NCc1ccc(CCCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H31N3O/c1-20(27)24-19-22-12-10-21(11-13-22)7-5-6-14-25-15-17-26(18-16-25)23-8-3-2-4-9-23/h2-4,8-13H,5-7,14-19H2,1H3,(H,24,27)
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6n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50088841
PNG
(CHEMBL352617 | N-{4-[3-(4-Phenyl-piperazin-1-yl)-p...)
Show SMILES CC(=O)NCc1ccc(CCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H29N3O/c1-19(26)23-18-21-11-9-20(10-12-21)6-5-13-24-14-16-25(17-15-24)22-7-3-2-4-8-22/h2-4,7-12H,5-6,13-18H2,1H3,(H,23,26)
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6.40n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452985
PNG
(CHEMBL2114234)
Show SMILES CCCCCCN1CCC[C@@H]1CNC(=O)c1cc(cc2C[C@H](C)Oc12)S(N)(=O)=O
Show InChI InChI=1S/C21H33N3O4S/c1-3-4-5-6-9-24-10-7-8-17(24)14-23-21(25)19-13-18(29(22,26)27)12-16-11-15(2)28-20(16)19/h12-13,15,17H,3-11,14H2,1-2H3,(H,23,25)(H2,22,26,27)/t15-,17+/m0/s1
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6.70n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50088844
PNG
(4-{4-[4-(4-Phenyl-piperazin-1-yl)-butyl]-phenyl}-t...)
Show SMILES Nc1nc(cs1)-c1ccc(CCCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H28N4S/c24-23-25-22(18-28-23)20-11-9-19(10-12-20)6-4-5-13-26-14-16-27(17-15-26)21-7-2-1-3-8-21/h1-3,7-12,18H,4-6,13-17H2,(H2,24,25)
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7.90n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of class C beta-lactamase derived from Enterobacter cloacae P99


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452983
PNG
(CHEMBL2114236)
Show SMILES CCCCN1CCC[C@@H]1CNC(=O)c1cc(cc2C[C@H](C)Oc12)S(N)(=O)=O
Show InChI InChI=1S/C19H29N3O4S/c1-3-4-7-22-8-5-6-15(22)12-21-19(23)17-11-16(27(20,24)25)10-14-9-13(2)26-18(14)17/h10-11,13,15H,3-9,12H2,1-2H3,(H,21,23)(H2,20,24,25)/t13-,15+/m0/s1
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9.40n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452981
PNG
(CHEMBL2115231)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(cc2C[C@H](C)Oc12)S(N)(=O)=O
Show InChI InChI=1S/C17H25N3O4S/c1-3-20-6-4-5-13(20)10-19-17(21)15-9-14(25(18,22)23)8-12-7-11(2)24-16(12)15/h8-9,11,13H,3-7,10H2,1-2H3,(H,19,21)(H2,18,22,23)/t11-,13-/m0/s1
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9.60n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452980
PNG
(CHEMBL2115232)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(cc2C[C@@H](C)Oc12)S(N)(=O)=O
Show InChI InChI=1S/C17H25N3O4S/c1-3-20-6-4-5-13(20)10-19-17(21)15-9-14(25(18,22)23)8-12-7-11(2)24-16(12)15/h8-9,11,13H,3-7,10H2,1-2H3,(H,19,21)(H2,18,22,23)/t11-,13+/m1/s1
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21n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452984
PNG
(CHEMBL2114235)
Show SMILES CCCCN1CCC[C@@H]1CNC(=O)c1cc(cc2C[C@@H](C)Oc12)S(N)(=O)=O
Show InChI InChI=1S/C19H29N3O4S/c1-3-4-7-22-8-5-6-15(22)12-21-19(23)17-11-16(27(20,24)25)10-14-9-13(2)26-18(14)17/h10-11,13,15H,3-9,12H2,1-2H3,(H,21,23)(H2,20,24,25)/t13-,15-/m1/s1
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23n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM81774
PNG
(CAS_15676-16-1 | SULPIRIDE,(+) | Sulpiride-S | Sul...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O
Show InChI InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1
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29n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50088841
PNG
(CHEMBL352617 | N-{4-[3-(4-Phenyl-piperazin-1-yl)-p...)
Show SMILES CC(=O)NCc1ccc(CCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H29N3O/c1-19(26)23-18-21-11-9-20(10-12-21)6-5-13-24-14-16-25(17-15-24)22-7-3-2-4-8-22/h2-4,7-12H,5-6,13-18H2,1H3,(H,23,26)
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33n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Homo sapiens (Human))
BDBM50088844
PNG
(4-{4-[4-(4-Phenyl-piperazin-1-yl)-butyl]-phenyl}-t...)
Show SMILES Nc1nc(cs1)-c1ccc(CCCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H28N4S/c24-23-25-22(18-28-23)20-11-9-19(10-12-20)6-4-5-13-26-14-16-27(17-15-26)21-7-2-1-3-8-21/h1-3,7-12,18H,4-6,13-17H2,(H2,24,25)
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37n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of GC1 extended spectrum class C beta-lactamase


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Homo sapiens (Human))
BDBM50088839
PNG
(CHEMBL169702 | N-{4-[4-(4-Phenyl-piperazin-1-yl)-b...)
Show SMILES CC(=O)NCc1ccc(CCCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H31N3O/c1-20(27)24-19-22-12-10-21(11-13-22)7-5-6-14-25-15-17-26(18-16-25)23-8-3-2-4-9-23/h2-4,8-13H,5-7,14-19H2,1H3,(H,24,27)
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48n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of GC1 extended spectrum class C beta-lactamase


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50088839
PNG
(CHEMBL169702 | N-{4-[4-(4-Phenyl-piperazin-1-yl)-b...)
Show SMILES CC(=O)NCc1ccc(CCCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H31N3O/c1-20(27)24-19-22-12-10-21(11-13-22)7-5-6-14-25-15-17-26(18-16-25)23-8-3-2-4-9-23/h2-4,8-13H,5-7,14-19H2,1H3,(H,24,27)
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49n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50284586
PNG
(CHEMBL22857 | N-((S)-1-Butyl-pyrrolidin-2-ylmethyl...)
Show SMILES CCCCN1CCC[C@H]1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O
Show InChI InChI=1S/C17H27N3O4S/c1-3-4-9-20-10-5-6-13(20)12-19-17(21)15-11-14(25(18,22)23)7-8-16(15)24-2/h7-8,11,13H,3-6,9-10,12H2,1-2H3,(H,19,21)(H2,18,22,23)/t13-/m0/s1
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51n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452990
PNG
(CHEMBL2114240)
Show SMILES CCCCCCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O
Show InChI InChI=1S/C19H31N3O4S/c1-3-4-5-6-11-22-12-7-8-15(22)14-21-19(23)17-13-16(27(20,24)25)9-10-18(17)26-2/h9-10,13,15H,3-8,11-12,14H2,1-2H3,(H,21,23)(H2,20,24,25)/t15-/m1/s1
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59n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50088846
PNG
(CHEMBL353678 | N-{4-[2-(4-Phenyl-piperazin-1-yl)-e...)
Show SMILES CC(=O)NCc1ccc(CCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C21H27N3O/c1-18(25)22-17-20-9-7-19(8-10-20)11-12-23-13-15-24(16-14-23)21-5-3-2-4-6-21/h2-10H,11-17H2,1H3,(H,22,25)
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69n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of human trypsin.


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452982
PNG
(CHEMBL2115229)
Show SMILES CCCCN1CCC[C@H]1CNC(=O)c1cc(cc2C[C@H](C)Oc12)S(N)(=O)=O
Show InChI InChI=1S/C19H29N3O4S/c1-3-4-7-22-8-5-6-15(22)12-21-19(23)17-11-16(27(20,24)25)10-14-9-13(2)26-18(14)17/h10-11,13,15H,3-9,12H2,1-2H3,(H,21,23)(H2,20,24,25)/t13-,15-/m0/s1
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95n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Homo sapiens (Human))
BDBM50088846
PNG
(CHEMBL353678 | N-{4-[2-(4-Phenyl-piperazin-1-yl)-e...)
Show SMILES CC(=O)NCc1ccc(CCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C21H27N3O/c1-18(25)22-17-20-9-7-19(8-10-20)11-12-23-13-15-24(16-14-23)21-5-3-2-4-6-21/h2-10H,11-17H2,1H3,(H,22,25)
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130n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of human thrombin.


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50088845
PNG
(CHEMBL170307 | N-[4-(4-Phenyl-piperazin-1-ylmethyl...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C20H25N3O/c1-17(24)21-15-18-7-9-19(10-8-18)16-22-11-13-23(14-12-22)20-5-3-2-4-6-20/h2-10H,11-16H2,1H3,(H,21,24)
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140n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Homo sapiens (Human))
BDBM50088841
PNG
(CHEMBL352617 | N-{4-[3-(4-Phenyl-piperazin-1-yl)-p...)
Show SMILES CC(=O)NCc1ccc(CCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H29N3O/c1-19(26)23-18-21-11-9-20(10-12-21)6-5-13-24-14-16-25(17-15-24)22-7-3-2-4-8-22/h2-4,7-12H,5-6,13-18H2,1H3,(H,23,26)
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160n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of GC1 extended spectrum class C beta-lactamase


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50088846
PNG
(CHEMBL353678 | N-{4-[2-(4-Phenyl-piperazin-1-yl)-e...)
Show SMILES CC(=O)NCc1ccc(CCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C21H27N3O/c1-18(25)22-17-20-9-7-19(8-10-20)11-12-23-13-15-24(16-14-23)21-5-3-2-4-6-21/h2-10H,11-17H2,1H3,(H,22,25)
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170n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452987
PNG
(CHEMBL2115228)
Show SMILES CCCCN1CCC[C@H]1CNC(=O)c1cc(cc2C[C@@H](C)Oc12)S(N)(=O)=O
Show InChI InChI=1S/C19H29N3O4S/c1-3-4-7-22-8-5-6-15(22)12-21-19(23)17-11-16(27(20,24)25)10-14-9-13(2)26-18(14)17/h10-11,13,15H,3-9,12H2,1-2H3,(H,21,23)(H2,20,24,25)/t13-,15+/m1/s1
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210n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50284609
PNG
(CHEMBL278762 | N-((R)-1-Butyl-pyrrolidin-2-ylmethy...)
Show SMILES CCCCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O
Show InChI InChI=1S/C17H27N3O4S/c1-3-4-9-20-10-5-6-13(20)12-19-17(21)15-11-14(25(18,22)23)7-8-16(15)24-2/h7-8,11,13H,3-6,9-10,12H2,1-2H3,(H,19,21)(H2,18,22,23)/t13-/m1/s1
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230n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50088841
PNG
(CHEMBL352617 | N-{4-[3-(4-Phenyl-piperazin-1-yl)-p...)
Show SMILES CC(=O)NCc1ccc(CCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H29N3O/c1-19(26)23-18-21-11-9-20(10-12-21)6-5-13-24-14-16-25(17-15-24)22-7-3-2-4-8-22/h2-4,7-12H,5-6,13-18H2,1H3,(H,23,26)
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340n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452988
PNG
(CHEMBL2114238)
Show SMILES CCN1CCC[C@@H]1CNC(=O)c1cc(cc2C[C@H](C)Oc12)S(N)(=O)=O
Show InChI InChI=1S/C17H25N3O4S/c1-3-20-6-4-5-13(20)10-19-17(21)15-9-14(25(18,22)23)8-12-7-11(2)24-16(12)15/h8-9,11,13H,3-7,10H2,1-2H3,(H,19,21)(H2,18,22,23)/t11-,13+/m0/s1
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400n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452986
PNG
(CHEMBL2115227)
Show SMILES CCCCCCN1CCC[C@H]1CNC(=O)c1cc(cc2C[C@H](C)Oc12)S(N)(=O)=O
Show InChI InChI=1S/C21H33N3O4S/c1-3-4-5-6-9-24-10-7-8-17(24)14-23-21(25)19-13-18(29(22,26)27)12-16-11-15(2)28-20(16)19/h12-13,15,17H,3-11,14H2,1-2H3,(H,23,25)(H2,22,26,27)/t15-,17-/m0/s1
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630n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452989
PNG
(CHEMBL2114239)
Show SMILES CCN1CCC[C@@H]1CNC(=O)c1cc(cc2C[C@@H](C)Oc12)S(N)(=O)=O
Show InChI InChI=1S/C17H25N3O4S/c1-3-20-6-4-5-13(20)10-19-17(21)15-9-14(25(18,22)23)8-12-7-11(2)24-16(12)15/h8-9,11,13H,3-7,10H2,1-2H3,(H,19,21)(H2,18,22,23)/t11-,13-/m1/s1
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650n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.


J Med Chem 34: 261-7 (1991)


Article DOI: 10.1021/jm00105a041
BindingDB Entry DOI: 10.7270/Q2W959SQ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Homo sapiens (Human))
BDBM50088847
PNG
(CHEMBL171345 | N-{4-[4-(4-Chloro-phenyl)-piperazin...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H24ClN3O/c1-16(25)22-14-17-2-4-18(5-3-17)15-23-10-12-24(13-11-23)20-8-6-19(21)7-9-20/h2-9H,10-15H2,1H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of class C beta-lactamase derived from Enterobacter cloacae P99


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50088842
PNG
(CHEMBL171052 | N-{4-[4-(4-Fluoro-phenyl)-piperazin...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H24FN3O/c1-16(25)22-14-17-2-4-18(5-3-17)15-23-10-12-24(13-11-23)20-8-6-19(21)7-9-20/h2-9H,10-15H2,1H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50088845
PNG
(CHEMBL170307 | N-[4-(4-Phenyl-piperazin-1-ylmethyl...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C20H25N3O/c1-17(24)21-15-18-7-9-19(10-8-18)16-22-11-13-23(14-12-22)20-5-3-2-4-6-20/h2-10H,11-16H2,1H3,(H,21,24)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of human plasmin.


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Homo sapiens (Human))
BDBM50088840
PNG
(CHEMBL352576 | N-{4-[4-(2,4-Difluoro-phenyl)-piper...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(F)cc2F)cc1
Show InChI InChI=1S/C20H23F2N3O/c1-15(26)23-13-16-2-4-17(5-3-16)14-24-8-10-25(11-9-24)20-7-6-18(21)12-19(20)22/h2-7,12H,8-11,13-14H2,1H3,(H,23,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of human thrombin.


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Homo sapiens (Human))
BDBM50088843
PNG
(CHEMBL171115 | N-{4-[4-(4-Methoxy-phenyl)-piperazi...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2ccc(CNC(C)=O)cc2)CC1
Show InChI InChI=1S/C21H27N3O2/c1-17(25)22-15-18-3-5-19(6-4-18)16-23-11-13-24(14-12-23)20-7-9-21(26-2)10-8-20/h3-10H,11-16H2,1-2H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50088843
PNG
(CHEMBL171115 | N-{4-[4-(4-Methoxy-phenyl)-piperazi...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2ccc(CNC(C)=O)cc2)CC1
Show InChI InChI=1S/C21H27N3O2/c1-17(25)22-15-18-3-5-19(6-4-18)16-23-11-13-24(14-12-23)20-7-9-21(26-2)10-8-20/h3-10H,11-16H2,1-2H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Alpha-1 adrenergic receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50088847
PNG
(CHEMBL171345 | N-{4-[4-(4-Chloro-phenyl)-piperazin...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H24ClN3O/c1-16(25)22-14-17-2-4-18(5-3-17)15-23-10-12-24(13-11-23)20-8-6-19(21)7-9-20/h2-9H,10-15H2,1H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of class C beta-lactamase derived from Enterobacter cloacae P99


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50088842
PNG
(CHEMBL171052 | N-{4-[4-(4-Fluoro-phenyl)-piperazin...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H24FN3O/c1-16(25)22-14-17-2-4-18(5-3-17)15-23-10-12-24(13-11-23)20-8-6-19(21)7-9-20/h2-9H,10-15H2,1H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50088847
PNG
(CHEMBL171345 | N-{4-[4-(4-Chloro-phenyl)-piperazin...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H24ClN3O/c1-16(25)22-14-17-2-4-18(5-3-17)15-23-10-12-24(13-11-23)20-8-6-19(21)7-9-20/h2-9H,10-15H2,1H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50088847
PNG
(CHEMBL171345 | N-{4-[4-(4-Chloro-phenyl)-piperazin...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H24ClN3O/c1-16(25)22-14-17-2-4-18(5-3-17)15-23-10-12-24(13-11-23)20-8-6-19(21)7-9-20/h2-9H,10-15H2,1H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50088840
PNG
(CHEMBL352576 | N-{4-[4-(2,4-Difluoro-phenyl)-piper...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(F)cc2F)cc1
Show InChI InChI=1S/C20H23F2N3O/c1-15(26)23-13-16-2-4-17(5-3-16)14-24-8-10-25(11-9-24)20-7-6-18(21)12-19(20)22/h2-7,12H,8-11,13-14H2,1H3,(H,23,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Alpha-1 adrenergic receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50088845
PNG
(CHEMBL170307 | N-[4-(4-Phenyl-piperazin-1-ylmethyl...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C20H25N3O/c1-17(24)21-15-18-7-9-19(10-8-18)16-22-11-13-23(14-12-22)20-5-3-2-4-6-20/h2-10H,11-16H2,1H3,(H,21,24)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50088843
PNG
(CHEMBL171115 | N-{4-[4-(4-Methoxy-phenyl)-piperazi...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2ccc(CNC(C)=O)cc2)CC1
Show InChI InChI=1S/C21H27N3O2/c1-17(25)22-15-18-3-5-19(6-4-18)16-23-11-13-24(14-12-23)20-7-9-21(26-2)10-8-20/h3-10H,11-16H2,1-2H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50088843
PNG
(CHEMBL171115 | N-{4-[4-(4-Methoxy-phenyl)-piperazi...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2ccc(CNC(C)=O)cc2)CC1
Show InChI InChI=1S/C21H27N3O2/c1-17(25)22-15-18-3-5-19(6-4-18)16-23-11-13-24(14-12-23)20-7-9-21(26-2)10-8-20/h3-10H,11-16H2,1-2H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50088842
PNG
(CHEMBL171052 | N-{4-[4-(4-Fluoro-phenyl)-piperazin...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H24FN3O/c1-16(25)22-14-17-2-4-18(5-3-17)15-23-10-12-24(13-11-23)20-8-6-19(21)7-9-20/h2-9H,10-15H2,1H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50088840
PNG
(CHEMBL352576 | N-{4-[4-(2,4-Difluoro-phenyl)-piper...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(F)cc2F)cc1
Show InChI InChI=1S/C20H23F2N3O/c1-15(26)23-13-16-2-4-17(5-3-16)14-24-8-10-25(11-9-24)20-7-6-18(21)12-19(20)22/h2-7,12H,8-11,13-14H2,1H3,(H,23,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50088840
PNG
(CHEMBL352576 | N-{4-[4-(2,4-Difluoro-phenyl)-piper...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(F)cc2F)cc1
Show InChI InChI=1S/C20H23F2N3O/c1-15(26)23-13-16-2-4-17(5-3-16)14-24-8-10-25(11-9-24)20-7-6-18(21)12-19(20)22/h2-7,12H,8-11,13-14H2,1H3,(H,23,26)
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PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Homo sapiens (Human))
BDBM50088842
PNG
(CHEMBL171052 | N-{4-[4-(4-Fluoro-phenyl)-piperazin...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H24FN3O/c1-16(25)22-14-17-2-4-18(5-3-17)15-23-10-12-24(13-11-23)20-8-6-19(21)7-9-20/h2-9H,10-15H2,1H3,(H,22,25)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2 receptor


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Homo sapiens (Human))
BDBM50088845
PNG
(CHEMBL170307 | N-[4-(4-Phenyl-piperazin-1-ylmethyl...)
Show SMILES CC(=O)NCc1ccc(CN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C20H25N3O/c1-17(24)21-15-18-7-9-19(10-8-18)16-22-11-13-23(14-12-22)20-5-3-2-4-6-20/h2-10H,11-16H2,1H3,(H,21,24)
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>1.00E+3n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of GC1 extended spectrum class C beta-lactamase


Bioorg Med Chem Lett 10: 875-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00128-1
BindingDB Entry DOI: 10.7270/Q2CZ36C7
More data for this
Ligand-Target Pair
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