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Compile Data Set for Download or QSAR

Found 148 hits with Last Name = 'giorgioni' and Initial = 'g'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D5 receptor


(Homo sapiens (Human)-RAT)
BDBM50164588
PNG
(1-[1-(2-Chloro-phenyl)-cyclopropyl]-6-fluoro-2-met...)
Show SMILES CN1CCc2cc(F)c(O)cc2C1C1(CC1)c1ccccc1Cl
Show InChI InChI=1S/C19H19ClFNO/c1-22-9-6-12-10-16(21)17(23)11-13(12)18(22)19(7-8-19)14-4-2-3-5-15(14)20/h2-5,10-11,18,23H,6-9H2,1H3
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0.180n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for Dopamine receptor D1-like


J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054088
PNG
((2R,3R)-2-(Methyl-propyl-amino)-3-phenyl-indan-5-o...)
Show SMILES CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C19H23NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h4-10,13,18-19,21H,3,11-12H2,1-2H3/t18-,19-/m1/s1
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0.340n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D2 in rat striatal homogenate by [3H]-spiperone displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054088
PNG
((2R,3R)-2-(Methyl-propyl-amino)-3-phenyl-indan-5-o...)
Show SMILES CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C19H23NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h4-10,13,18-19,21H,3,11-12H2,1-2H3/t18-,19-/m1/s1
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0.340n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D2 in rat striatal homogenate by [3H]-spiperone displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054084
PNG
((2R,3R)-2-(Allyl-methyl-amino)-3-phenyl-indan-5-ol...)
Show SMILES CN(CC=C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C19H21NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h3-10,13,18-19,21H,1,11-12H2,2H3/t18-,19-/m1/s1
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0.430n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D2 in rat striatal homogenate by [3H]-spiperone displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054084
PNG
((2R,3R)-2-(Allyl-methyl-amino)-3-phenyl-indan-5-ol...)
Show SMILES CN(CC=C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C19H21NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h3-10,13,18-19,21H,1,11-12H2,2H3/t18-,19-/m1/s1
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0.430n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D2 in rat striatal homogenate by [3H]-spiperone displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054089
PNG
((2R,3R)-2-Amino-3-phenyl-indan-5-ol | CHEMBL135224)
Show SMILES N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C15H15NO/c16-14-8-11-6-7-12(17)9-13(11)15(14)10-4-2-1-3-5-10/h1-7,9,14-15,17H,8,16H2/t14-,15-/m1/s1
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0.590n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D2 in rat striatal homogenate by [3H]-spiperone displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054089
PNG
((2R,3R)-2-Amino-3-phenyl-indan-5-ol | CHEMBL135224)
Show SMILES N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C15H15NO/c16-14-8-11-6-7-12(17)9-13(11)15(14)10-4-2-1-3-5-10/h1-7,9,14-15,17H,8,16H2/t14-,15-/m1/s1
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0.590n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D2 in rat striatal homogenate by [3H]-spiperone displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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0.730n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054084
PNG
((2R,3R)-2-(Allyl-methyl-amino)-3-phenyl-indan-5-ol...)
Show SMILES CN(CC=C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C19H21NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h3-10,13,18-19,21H,1,11-12H2,2H3/t18-,19-/m1/s1
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0.790n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054084
PNG
((2R,3R)-2-(Allyl-methyl-amino)-3-phenyl-indan-5-ol...)
Show SMILES CN(CC=C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C19H21NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h3-10,13,18-19,21H,1,11-12H2,2H3/t18-,19-/m1/s1
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0.790n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054091
PNG
((2R,3R)-2-Dipropylamino-3-phenyl-indan-5-ol | CHEM...)
Show SMILES CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C21H27NO/c1-3-12-22(13-4-2)20-14-17-10-11-18(23)15-19(17)21(20)16-8-6-5-7-9-16/h5-11,15,20-21,23H,3-4,12-14H2,1-2H3/t20-,21-/m1/s1
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0.840n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D2 in rat striatal homogenate by [3H]-spiperone displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054091
PNG
((2R,3R)-2-Dipropylamino-3-phenyl-indan-5-ol | CHEM...)
Show SMILES CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C21H27NO/c1-3-12-22(13-4-2)20-14-17-10-11-18(23)15-19(17)21(20)16-8-6-5-7-9-16/h5-11,15,20-21,23H,3-4,12-14H2,1-2H3/t20-,21-/m1/s1
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0.840n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D2 in rat striatal homogenate by [3H]-spiperone displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054088
PNG
((2R,3R)-2-(Methyl-propyl-amino)-3-phenyl-indan-5-o...)
Show SMILES CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C19H23NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h4-10,13,18-19,21H,3,11-12H2,1-2H3/t18-,19-/m1/s1
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0.900n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054088
PNG
((2R,3R)-2-(Methyl-propyl-amino)-3-phenyl-indan-5-o...)
Show SMILES CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C19H23NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h4-10,13,18-19,21H,3,11-12H2,1-2H3/t18-,19-/m1/s1
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0.900n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054090
PNG
((1R,2R)-2-Dipropylamino-1-phenyl-indan-5-ol | CHEM...)
Show SMILES CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1
Show InChI InChI=1S/C21H27NO/c1-3-12-22(13-4-2)20-15-17-14-18(23)10-11-19(17)21(20)16-8-6-5-7-9-16/h5-11,14,20-21,23H,3-4,12-13,15H2,1-2H3/t20-,21-/m1/s1
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1.80n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054090
PNG
((1R,2R)-2-Dipropylamino-1-phenyl-indan-5-ol | CHEM...)
Show SMILES CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1
Show InChI InChI=1S/C21H27NO/c1-3-12-22(13-4-2)20-15-17-14-18(23)10-11-19(17)21(20)16-8-6-5-7-9-16/h5-11,14,20-21,23H,3-4,12-13,15H2,1-2H3/t20-,21-/m1/s1
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1.80n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50200351
PNG
((+/-)-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chrom...)
Show SMILES Oc1cc2OCC3NCc4ccccc4C3c2cc1O
Show InChI InChI=1S/C16H15NO3/c18-13-5-11-15(6-14(13)19)20-8-12-16(11)10-4-2-1-3-9(10)7-17-12/h1-6,12,16-19H,7-8H2
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2n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha 2C receptor receptor


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054089
PNG
((2R,3R)-2-Amino-3-phenyl-indan-5-ol | CHEMBL135224)
Show SMILES N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C15H15NO/c16-14-8-11-6-7-12(17)9-13(11)15(14)10-4-2-1-3-5-10/h1-7,9,14-15,17H,8,16H2/t14-,15-/m1/s1
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2.5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054089
PNG
((2R,3R)-2-Amino-3-phenyl-indan-5-ol | CHEMBL135224)
Show SMILES N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C15H15NO/c16-14-8-11-6-7-12(17)9-13(11)15(14)10-4-2-1-3-5-10/h1-7,9,14-15,17H,8,16H2/t14-,15-/m1/s1
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2.5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054087
PNG
(6-[(3-Amino-propyl)-phenethyl-amino]-5,6,7,8-tetra...)
Show SMILES NCCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H28N2O/c22-13-5-14-23(15-12-17-6-2-1-3-7-17)19-10-11-20-18(16-19)8-4-9-21(20)24/h1-4,6-9,19,24H,5,10-16,22H2
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2.70n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D2 in rat striatal homogenate by [3H]-spiperone displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054093
PNG
((1R,2R)-2-Amino-1,2-dimethyl-1-phenyl-indan-5,6-di...)
Show SMILES C[C@@]1(N)Cc2cc(O)c(O)cc2[C@@]1(C)c1ccccc1
Show InChI InChI=1S/C17H19NO2/c1-16(18)10-11-8-14(19)15(20)9-13(11)17(16,2)12-6-4-3-5-7-12/h3-9,19-20H,10,18H2,1-2H3/t16-,17-/m1/s1
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5.5n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50200351
PNG
((+/-)-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chrom...)
Show SMILES Oc1cc2OCC3NCc4ccccc4C3c2cc1O
Show InChI InChI=1S/C16H15NO3/c18-13-5-11-15(6-14(13)19)20-8-12-16(11)10-4-2-1-3-9(10)7-17-12/h1-6,12,16-19H,7-8H2
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7n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D5 receptor


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50200353
PNG
((6aR,12bS)-(+)-2,3-dihydroxy-6a,7,8,12b-tetrahydro...)
Show SMILES Oc1cc2OC[C@H]3NCc4ccccc4[C@@H]3c2cc1O
Show InChI InChI=1S/C16H15NO3/c18-13-5-11-15(6-14(13)19)20-8-12-16(11)10-4-2-1-3-9(10)7-17-12/h1-6,12,16-19H,7-8H2/t12-,16-/m1/s1
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8n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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8n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2-like receptor in porcine striata homogenate


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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8.10n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes


J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50200351
PNG
((+/-)-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chrom...)
Show SMILES Oc1cc2OCC3NCc4ccccc4C3c2cc1O
Show InChI InChI=1S/C16H15NO3/c18-13-5-11-15(6-14(13)19)20-8-12-16(11)10-4-2-1-3-9(10)7-17-12/h1-6,12,16-19H,7-8H2
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10n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha 2B receptor receptor


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054085
PNG
((1R,2R)-2-Amino-1-phenyl-indan-5-ol | CHEMBL336366)
Show SMILES N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1
Show InChI InChI=1S/C15H15NO/c16-14-9-11-8-12(17)6-7-13(11)15(14)10-4-2-1-3-5-10/h1-8,14-15,17H,9,16H2/t14-,15-/m1/s1
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19n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054085
PNG
((1R,2R)-2-Amino-1-phenyl-indan-5-ol | CHEMBL336366)
Show SMILES N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1
Show InChI InChI=1S/C15H15NO/c16-14-9-11-8-12(17)6-7-13(11)15(14)10-4-2-1-3-5-10/h1-8,14-15,17H,9,16H2/t14-,15-/m1/s1
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19n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50010686
PNG
((6aR,12bS)-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydr...)
Show SMILES Oc1cc2CC[C@H]3NCc4ccccc4[C@@H]3c2cc1O
Show InChI InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m1/s1
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21n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50200351
PNG
((+/-)-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chrom...)
Show SMILES Oc1cc2OCC3NCc4ccccc4C3c2cc1O
Show InChI InChI=1S/C16H15NO3/c18-13-5-11-15(6-14(13)19)20-8-12-16(11)10-4-2-1-3-9(10)7-17-12/h1-6,12,16-19H,7-8H2
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22n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054091
PNG
((2R,3R)-2-Dipropylamino-3-phenyl-indan-5-ol | CHEM...)
Show SMILES CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C21H27NO/c1-3-12-22(13-4-2)20-14-17-10-11-18(23)15-19(17)21(20)16-8-6-5-7-9-16/h5-11,15,20-21,23H,3-4,12-14H2,1-2H3/t20-,21-/m1/s1
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26n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50054091
PNG
((2R,3R)-2-Dipropylamino-3-phenyl-indan-5-ol | CHEM...)
Show SMILES CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C21H27NO/c1-3-12-22(13-4-2)20-14-17-10-11-18(23)15-19(17)21(20)16-8-6-5-7-9-16/h5-11,15,20-21,23H,3-4,12-14H2,1-2H3/t20-,21-/m1/s1
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26n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.


J Med Chem 39: 4238-46 (1996)


Article DOI: 10.1021/jm960318v
BindingDB Entry DOI: 10.7270/Q2WQ04FD
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50200351
PNG
((+/-)-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chrom...)
Show SMILES Oc1cc2OCC3NCc4ccccc4C3c2cc1O
Show InChI InChI=1S/C16H15NO3/c18-13-5-11-15(6-14(13)19)20-8-12-16(11)10-4-2-1-3-9(10)7-17-12/h1-6,12,16-19H,7-8H2
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90n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D4 receptor


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50200351
PNG
((+/-)-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chrom...)
Show SMILES Oc1cc2OCC3NCc4ccccc4C3c2cc1O
Show InChI InChI=1S/C16H15NO3/c18-13-5-11-15(6-14(13)19)20-8-12-16(11)10-4-2-1-3-9(10)7-17-12/h1-6,12,16-19H,7-8H2
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98n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D1 receptor


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50164591
PNG
(((1R,2R)-5-Fluoro-6-methoxy-1-phenyl-indan-2-yl)-d...)
Show SMILES CCCN(CCC)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C22H28FNO/c1-4-11-24(12-5-2)20-14-17-13-19(23)21(25-3)15-18(17)22(20)16-9-7-6-8-10-16/h6-10,13,15,20,22H,4-5,11-12,14H2,1-3H3/t20-,22-/m1/s1
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170n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for [3H]YM-09151-2 binding to Dopamine receptor D2-like in porcine striatal membranes


J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50200351
PNG
((+/-)-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chrom...)
Show SMILES Oc1cc2OCC3NCc4ccccc4C3c2cc1O
Show InChI InChI=1S/C16H15NO3/c18-13-5-11-15(6-14(13)19)20-8-12-16(11)10-4-2-1-3-9(10)7-17-12/h1-6,12,16-19H,7-8H2
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180n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha 2A receptor


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50164580
PNG
((1R,2R)-6-Fluoro-2-(methyl-propyl-amino)-1-phenyl-...)
Show SMILES CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C19H22FNO/c1-3-9-21(2)17-10-14-11-18(22)16(20)12-15(14)19(17)13-7-5-4-6-8-13/h4-8,11-12,17,19,22H,3,9-10H2,1-2H3/t17-,19-/m1/s1
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240n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for [3H]YM-09151-2 binding to Dopamine receptor D2-like in porcine striatal membranes


J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50010686
PNG
((6aR,12bS)-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydr...)
Show SMILES Oc1cc2CC[C@H]3NCc4ccccc4[C@@H]3c2cc1O
Show InChI InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m1/s1
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240n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2-like receptor in porcine striata homogenate


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50200352
PNG
((6aS,12bR)-(-)-2,3-dihydroxy-6a,7,8,12b-tetrahydro...)
Show SMILES Oc1cc2OC[C@@H]3NCc4ccccc4[C@H]3c2cc1O
Show InChI InChI=1S/C16H15NO3/c18-13-5-11-15(6-14(13)19)20-8-12-16(11)10-4-2-1-3-9(10)7-17-12/h1-6,12,16-19H,7-8H2/t12-,16-/m0/s1
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270n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50164593
PNG
(((1R,2R)-6-Fluoro-5-methoxy-1-phenyl-indan-2-yl)-m...)
Show SMILES CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C20H24FNO/c1-4-10-22(2)18-11-15-12-19(23-3)17(21)13-16(15)20(18)14-8-6-5-7-9-14/h5-9,12-13,18,20H,4,10-11H2,1-3H3/t18-,20-/m1/s1
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270n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for [3H]YM-09151-2 binding to Dopamine receptor D2-like in porcine striatal membranes


J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50164604
PNG
(Allyl-((1R,2R)-6-fluoro-5-methoxy-1-phenyl-indan-2...)
Show SMILES COc1cc2C[C@H]([C@@H](c2cc1F)c1ccccc1)N(C)CC=C
Show InChI InChI=1S/C20H22FNO/c1-4-10-22(2)18-11-15-12-19(23-3)17(21)13-16(15)20(18)14-8-6-5-7-9-14/h4-9,12-13,18,20H,1,10-11H2,2-3H3/t18-,20-/m1/s1
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310n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for [3H]YM-09151-2 binding to Dopamine receptor D2-like in porcine striatal membranes


J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50370760
PNG
(CHEMBL1203924)
Show SMILES CCCN1Cc2ccccc2C2C1COc1cc(O)c(O)cc21
Show InChI InChI=1S/C19H21NO3/c1-2-7-20-10-12-5-3-4-6-13(12)19-14-8-16(21)17(22)9-18(14)23-11-15(19)20/h3-6,8-9,15,19,21-22H,2,7,10-11H2,1H3
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330n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50370760
PNG
(CHEMBL1203924)
Show SMILES CCCN1Cc2ccccc2C2C1COc1cc(O)c(O)cc21
Show InChI InChI=1S/C19H21NO3/c1-2-7-20-10-12-5-3-4-6-13(12)19-14-8-16(21)17(22)9-18(14)23-11-15(19)20/h3-6,8-9,15,19,21-22H,2,7,10-11H2,1H3
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340n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2-like receptor in porcine striata homogenate


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50200351
PNG
((+/-)-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chrom...)
Show SMILES Oc1cc2OCC3NCc4ccccc4C3c2cc1O
Show InChI InChI=1S/C16H15NO3/c18-13-5-11-15(6-14(13)19)20-8-12-16(11)10-4-2-1-3-9(10)7-17-12/h1-6,12,16-19H,7-8H2
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390n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D3 receptor


J Med Chem 49: 6848-57 (2006)


Article DOI: 10.1021/jm0604979
BindingDB Entry DOI: 10.7270/Q25T3M92
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50164605
PNG
(((1R,2R)-5-Fluoro-6-methoxy-1-phenyl-indan-2-yl)-m...)
Show SMILES CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C20H24FNO/c1-4-10-22(2)18-12-15-11-17(21)19(23-3)13-16(15)20(18)14-8-6-5-7-9-14/h5-9,11,13,18,20H,4,10,12H2,1-3H3/t18-,20-/m1/s1
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480n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for [3H]YM-09151-2 binding to Dopamine receptor D2-like in porcine striatal membranes


J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50164595
PNG
(((1R,2R)-6-Fluoro-5-methoxy-1-phenyl-indan-2-yl)-d...)
Show SMILES CCCN(CCC)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C22H28FNO/c1-4-11-24(12-5-2)20-13-17-14-21(25-3)19(23)15-18(17)22(20)16-9-7-6-8-10-16/h6-10,14-15,20,22H,4-5,11-13H2,1-3H3/t20-,22-/m1/s1
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550n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for [3H]YM-09151-2 binding to Dopamine receptor D2-like in porcine striatal membranes


J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50164598
PNG
((1R,2R)-2-(Allyl-methyl-amino)-6-fluoro-1-phenyl-i...)
Show SMILES CN(CC=C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C19H20FNO/c1-3-9-21(2)17-10-14-11-18(22)16(20)12-15(14)19(17)13-7-5-4-6-8-13/h3-8,11-12,17,19,22H,1,9-10H2,2H3/t17-,19-/m1/s1
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640n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for [3H]YM-09151-2 binding to Dopamine receptor D2-like in porcine striatal membranes


J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50164587
PNG
(Allyl-((1R,2R)-5-fluoro-6-methoxy-1-phenyl-indan-2...)
Show SMILES COc1cc2[C@H]([C@@H](Cc2cc1F)N(C)CC=C)c1ccccc1
Show InChI InChI=1S/C20H22FNO/c1-4-10-22(2)18-12-15-11-17(21)19(23-3)13-16(15)20(18)14-8-6-5-7-9-14/h4-9,11,13,18,20H,1,10,12H2,2-3H3/t18-,20-/m1/s1
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640n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for [3H]YM-09151-2 binding to Dopamine receptor D2-like in porcine striatal membranes


J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50164590
PNG
((2R,3R)-6-Fluoro-2-(methyl-propyl-amino)-3-phenyl-...)
Show SMILES CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1
Show InChI InChI=1S/C19H22FNO/c1-3-9-21(2)17-11-14-10-16(20)18(22)12-15(14)19(17)13-7-5-4-6-8-13/h4-8,10,12,17,19,22H,3,9,11H2,1-2H3/t17-,19-/m1/s1
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650n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for [3H]YM-09151-2 binding to Dopamine receptor D2-like in porcine striatal membranes


J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
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