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Compile Data Set for Download or QSAR

Found 820 hits with Last Name = 'jiang' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331161
PNG
(4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-i...)
Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc2n(CCN3CCCC3)ncc2c1
Show InChI InChI=1S/C25H26N4O2/c30-25-17-23(31-19-20-6-2-1-3-7-20)10-13-28(25)22-8-9-24-21(16-22)18-26-29(24)15-14-27-11-4-5-12-27/h1-3,6-10,13,16-18H,4-5,11-12,14-15,19H2
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2.60n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331251
PNG
((R)-4-(benzyloxy)-1-(1-(2-(2-(hydroxymethyl)pyrrol...)
Show SMILES OC[C@H]1CCCN1CCn1ncc2cc(ccc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C26H28N4O3/c31-18-23-7-4-11-28(23)13-14-30-25-9-8-22(15-21(25)17-27-30)29-12-10-24(16-26(29)32)33-19-20-5-2-1-3-6-20/h1-3,5-6,8-10,12,15-17,23,31H,4,7,11,13-14,18-19H2/t23-/m1/s1
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3.10n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331242
PNG
(2-(4-chloro-2-fluorophenyl)-5-(1-(2-(pyrrolidin-1-...)
Show SMILES Fc1cc(Cl)ccc1-c1cc2c(ccn(-c3ccc4n(CCN5CCCC5)ncc4c3)c2=O)o1
Show InChI InChI=1S/C26H22ClFN4O2/c27-18-3-5-20(22(28)14-18)25-15-21-24(34-25)7-10-31(26(21)33)19-4-6-23-17(13-19)16-29-32(23)12-11-30-8-1-2-9-30/h3-7,10,13-16H,1-2,8-9,11-12H2
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4.20n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331234
PNG
((S)-4-(benzyloxy)-1-(1-(2-(3-hydroxypyrrolidin-1-y...)
Show SMILES O[C@H]1CCN(CCn2ncc3cc(ccc23)-n2ccc(OCc3ccccc3)cc2=O)C1
Show InChI InChI=1S/C25H26N4O3/c30-22-8-10-27(17-22)12-13-29-24-7-6-21(14-20(24)16-26-29)28-11-9-23(15-25(28)31)32-18-19-4-2-1-3-5-19/h1-7,9,11,14-16,22,30H,8,10,12-13,17-18H2/t22-/m0/s1
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4.70n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331245
PNG
(4-(benzyloxy)-1-(1-(2-(dimethylamino)ethyl)-1H-ind...)
Show SMILES CN(C)CCn1ncc2cc(ccc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C23H24N4O2/c1-25(2)12-13-27-22-9-8-20(14-19(22)16-24-27)26-11-10-21(15-23(26)28)29-17-18-6-4-3-5-7-18/h3-11,14-16H,12-13,17H2,1-2H3
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4.70n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331236
PNG
(2-(4-chlorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)...)
Show SMILES Clc1ccc(cc1)-c1cc2c(ccn(-c3ccc4n(CCN5CCCC5)ncc4c3)c2=O)o1
Show InChI InChI=1S/C26H23ClN4O2/c27-20-5-3-18(4-6-20)25-16-22-24(33-25)9-12-30(26(22)32)21-7-8-23-19(15-21)17-28-31(23)14-13-29-10-1-2-11-29/h3-9,12,15-17H,1-2,10-11,13-14H2
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5.20n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109806
PNG
(US8618299, 24)
Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc2c3C4CCCN4CCc3[nH]c2c1
Show InChI InChI=1S/C26H25N3O2/c30-25-16-20(31-17-18-5-2-1-3-6-18)10-14-29(25)19-8-9-21-23(15-19)27-22-11-13-28-12-4-7-24(28)26(21)22/h1-3,5-6,8-10,14-16,24,27H,4,7,11-13,17H2
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6n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331239
PNG
(2-(4-fluorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)...)
Show SMILES Fc1ccc(cc1)-c1cc2c(ccn(-c3ccc4n(CCN5CCCC5)ncc4c3)c2=O)o1
Show InChI InChI=1S/C26H23FN4O2/c27-20-5-3-18(4-6-20)25-16-22-24(33-25)9-12-30(26(22)32)21-7-8-23-19(15-21)17-28-31(23)14-13-29-10-1-2-11-29/h3-9,12,15-17H,1-2,10-11,13-14H2
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6.10n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109798
PNG
(US8618299, 16)
Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc2c3CN4CCCC4Cc3[nH]c2c1
Show InChI InChI=1S/C26H25N3O2/c30-26-15-21(31-17-18-5-2-1-3-6-18)10-12-29(26)20-8-9-22-23-16-28-11-4-7-19(28)13-25(23)27-24(22)14-20/h1-3,5-6,8-10,12,14-15,19,27H,4,7,11,13,16-17H2
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7n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109818
PNG
(US8618299, 36)
Show SMILES Cn1c2CC3CCCCN3Cc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C27H25F3N4O/c1-32-23-14-20(6-7-21(23)22-16-33-10-3-2-4-19(33)13-24(22)32)34-11-9-17(12-26(34)35)18-5-8-25(31-15-18)27(28,29)30/h5-9,11-12,14-15,19H,2-4,10,13,16H2,1H3
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7n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109793
PNG
(US8618299, 11)
Show SMILES Cn1c2CC3CCCN3Cc2c2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C27H27N3O2/c1-28-25-15-21(9-10-23(25)24-17-29-12-5-8-20(29)14-26(24)28)30-13-11-22(16-27(30)31)32-18-19-6-3-2-4-7-19/h2-4,6-7,9-11,13,15-16,20H,5,8,12,14,17-18H2,1H3
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8.10n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109812
PNG
(US8618299, 30)
Show SMILES Cn1c2CC3CCCN3Cc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C26H23F3N4O/c1-31-22-13-19(5-6-20(22)21-15-32-9-2-3-18(32)12-23(21)31)33-10-8-16(11-25(33)34)17-4-7-24(30-14-17)26(27,28)29/h4-8,10-11,13-14,18H,2-3,9,12,15H2,1H3
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8.30n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109803
PNG
(US8618299, 21)
Show SMILES Cn1c2CCN3CCCCC3c2c2ccc(cc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C27H27FN4O2/c1-30-23-10-12-31-11-3-2-4-24(31)27(23)22-8-7-20(14-25(22)30)32-13-9-21(15-26(32)33)34-17-19-6-5-18(28)16-29-19/h5-9,13-16,24H,2-4,10-12,17H2,1H3
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8.40n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109821
PNG
(US8618299, 39)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccn(-c2ccc3c4CN5CCCC5Cc4[nH]c3c2)c(=O)c1
Show InChI InChI=1S/C26H22F3N3O/c27-26(28,29)18-5-3-16(4-6-18)17-9-11-32(25(33)12-17)20-7-8-21-22-15-31-10-1-2-19(31)13-24(22)30-23(21)14-20/h3-9,11-12,14,19,30H,1-2,10,13,15H2
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8.5n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109811
PNG
(US8618299, 29)
Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc2c3CN4CCCCC4Cc3[nH]c2c1
Show InChI InChI=1S/C27H27N3O2/c31-27-16-22(32-18-19-6-2-1-3-7-19)11-13-30(27)21-9-10-23-24-17-29-12-5-4-8-20(29)14-26(24)28-25(23)15-21/h1-3,6-7,9-11,13,15-16,20,28H,4-5,8,12,14,17-18H2
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8.5n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331248
PNG
((S)-4-(benzyloxy)-1-(1-(2-(3-methoxypyrrolidin-1-y...)
Show SMILES CO[C@H]1CCN(CCn2ncc3cc(ccc23)-n2ccc(OCc3ccccc3)cc2=O)C1
Show InChI InChI=1S/C26H28N4O3/c1-32-24-9-11-28(18-24)13-14-30-25-8-7-22(15-21(25)17-27-30)29-12-10-23(16-26(29)31)33-19-20-5-3-2-4-6-20/h2-8,10,12,15-17,24H,9,11,13-14,18-19H2,1H3/t24-/m0/s1
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9.40n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331244
PNG
(2-phenyl-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazo...)
Show SMILES O=c1n(ccc2oc(cc12)-c1ccccc1)-c1ccc2n(CCN3CCCC3)ncc2c1
Show InChI InChI=1S/C26H24N4O2/c31-26-22-17-25(19-6-2-1-3-7-19)32-24(22)10-13-29(26)21-8-9-23-20(16-21)18-27-30(23)15-14-28-11-4-5-12-28/h1-3,6-10,13,16-18H,4-5,11-12,14-15H2
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9.70n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109794
PNG
(US8618299, 12)
Show SMILES Cn1c2CC3CCCN3Cc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C26H25FN4O2/c1-29-24-12-20(6-7-22(24)23-15-30-9-2-3-19(30)11-25(23)29)31-10-8-21(13-26(31)32)33-16-18-5-4-17(27)14-28-18/h4-8,10,12-14,19H,2-3,9,11,15-16H2,1H3
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9.70n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109819
PNG
(US8618299, 37 | US8618299, 38)
Show SMILES Cn1c2CC3CCCCN3Cc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C27H27FN4O2/c1-30-25-13-21(7-8-23(25)24-16-31-10-3-2-4-20(31)12-26(24)30)32-11-9-22(14-27(32)33)34-17-19-6-5-18(28)15-29-19/h5-9,11,13-15,20H,2-4,10,12,16-17H2,1H3
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10n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109829
PNG
(US8618299, 47)
Show SMILES Cn1c2CCN3CCCC3c2c2ccc(nc12)-n1ccc(OCc2ccc(Cl)cc2F)cc1=O
Show InChI InChI=1S/C26H24ClFN4O2/c1-30-21-9-11-31-10-2-3-22(31)25(21)19-6-7-23(29-26(19)30)32-12-8-18(14-24(32)33)34-15-16-4-5-17(27)13-20(16)28/h4-8,12-14,22H,2-3,9-11,15H2,1H3
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10n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109801
PNG
(US8618299, 19)
Show SMILES Cn1c2CCN3CCCC3c2c2ccc(cc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C26H25FN4O2/c1-29-22-9-11-30-10-2-3-23(30)26(22)21-7-6-19(13-24(21)29)31-12-8-20(14-25(31)32)33-16-18-5-4-17(27)15-28-18/h4-8,12-15,23H,2-3,9-11,16H2,1H3
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11n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331252
PNG
((R)-4-(benzyloxy)-1-(1-(2-(2-(methoxymethyl)pyrrol...)
Show SMILES COC[C@H]1CCCN1CCn1ncc2cc(ccc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C27H30N4O3/c1-33-20-24-8-5-12-29(24)14-15-31-26-10-9-23(16-22(26)18-28-31)30-13-11-25(17-27(30)32)34-19-21-6-3-2-4-7-21/h2-4,6-7,9-11,13,16-18,24H,5,8,12,14-15,19-20H2,1H3/t24-/m1/s1
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11.2n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331249
PNG
((S)-4-(benzyloxy)-1-(1-(pyrrolidin-2-ylmethyl)-1H-...)
Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc2n(C[C@@H]3CCCN3)ncc2c1
Show InChI InChI=1S/C24H24N4O2/c29-24-14-22(30-17-18-5-2-1-3-6-18)10-12-27(24)21-8-9-23-19(13-21)15-26-28(23)16-20-7-4-11-25-20/h1-3,5-6,8-10,12-15,20,25H,4,7,11,16-17H2/t20-/m0/s1
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12n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109826
PNG
(US8618299, 44)
Show SMILES Cn1c2CCN3CCCC3c2c2ccc(nc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C26H26N4O2/c1-28-21-12-14-29-13-5-8-22(29)25(21)20-9-10-23(27-26(20)28)30-15-11-19(16-24(30)31)32-17-18-6-3-2-4-7-18/h2-4,6-7,9-11,15-16,22H,5,8,12-14,17H2,1H3
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12n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109808
PNG
(US8618299, 26)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccn(-c2ccc3c4C5CCCN5CCc4[nH]c3c2)c(=O)c1
Show InChI InChI=1S/C26H22F3N3O/c27-26(28,29)18-5-3-16(4-6-18)17-9-13-32(24(33)14-17)19-7-8-20-22(15-19)30-21-10-12-31-11-1-2-23(31)25(20)21/h3-9,13-15,23,30H,1-2,10-12H2
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12n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109810
PNG
(US8618299, 28)
Show SMILES Fc1ccc(COc2ccn(-c3ccc4c5C6CCCN6CCc5[nH]c4c3)c(=O)c2)c(F)c1
Show InChI InChI=1S/C26H23F2N3O2/c27-17-4-3-16(21(28)12-17)15-33-19-7-11-31(25(32)14-19)18-5-6-20-23(13-18)29-22-8-10-30-9-1-2-24(30)26(20)22/h3-7,11-14,24,29H,1-2,8-10,15H2
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12n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109800
PNG
(US8618299, 18)
Show SMILES Cn1c2CCN3CCCC3c2c2ccc(cc12)-n1ccc(OCc2ccc(nc2)C(F)(F)F)cc1=O
Show InChI InChI=1S/C27H25F3N4O2/c1-32-21-9-11-33-10-2-3-22(33)26(21)20-6-5-18(13-23(20)32)34-12-8-19(14-25(34)35)36-16-17-4-7-24(31-15-17)27(28,29)30/h4-8,12-15,22H,2-3,9-11,16H2,1H3
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12n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109799
PNG
(US8618299, 17)
Show SMILES Cn1c2CCN3CCCC3c2c2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C27H27N3O2/c1-28-23-12-14-29-13-5-8-24(29)27(23)22-10-9-20(16-25(22)28)30-15-11-21(17-26(30)31)32-18-19-6-3-2-4-7-19/h2-4,6-7,9-11,15-17,24H,5,8,12-14,18H2,1H3
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12n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109784
PNG
(US8618299, 2 | US8618299, 3 | US8618299, 4)
Show SMILES Cn1c2C3CCCN3CCc2c2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C27H27N3O2/c1-28-25-16-20(9-10-22(25)23-12-14-29-13-5-8-24(29)27(23)28)30-15-11-21(17-26(30)31)32-18-19-6-3-2-4-7-19/h2-4,6-7,9-11,15-17,24H,5,8,12-14,18H2,1H3
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12.3n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331246
PNG
(4-(benzyloxy)-1-(1-(3-(dimethylamino)propyl)-1H-in...)
Show SMILES CN(C)CCCn1ncc2cc(ccc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C24H26N4O2/c1-26(2)12-6-13-28-23-10-9-21(15-20(23)17-25-28)27-14-11-22(16-24(27)29)30-18-19-7-4-3-5-8-19/h3-5,7-11,14-17H,6,12-13,18H2,1-2H3
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12.6n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109802
PNG
(US8618299, 20)
Show SMILES Cc1ccc(COc2ccn(-c3ccc4c5C6CCCN6CCc5n(C)c4c3)c(=O)c2)cn1
Show InChI InChI=1S/C27H28N4O2/c1-18-5-6-19(16-28-18)17-33-21-9-13-31(26(32)15-21)20-7-8-22-25(14-20)29(2)23-10-12-30-11-3-4-24(30)27(22)23/h5-9,13-16,24H,3-4,10-12,17H2,1-2H3
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13n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331243
PNG
(2-(2,4-dichlorophenyl)-5-(1-(2-(pyrrolidin-1-yl)et...)
Show SMILES Clc1ccc(-c2cc3c(ccn(-c4ccc5n(CCN6CCCC6)ncc5c4)c3=O)o2)c(Cl)c1
Show InChI InChI=1S/C26H22Cl2N4O2/c27-18-3-5-20(22(28)14-18)25-15-21-24(34-25)7-10-31(26(21)33)19-4-6-23-17(13-19)16-29-32(23)12-11-30-8-1-2-9-30/h3-7,10,13-16H,1-2,8-9,11-12H2
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14n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109807
PNG
(US8618299, 25)
Show SMILES Fc1ccc(COc2ccn(-c3ccc4c5C6CCCN6CCc5[nH]c4c3)c(=O)c2)nc1
Show InChI InChI=1S/C25H23FN4O2/c26-16-3-4-17(27-14-16)15-32-19-7-11-30(24(31)13-19)18-5-6-20-22(12-18)28-21-8-10-29-9-1-2-23(29)25(20)21/h3-7,11-14,23,28H,1-2,8-10,15H2
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14n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109822
PNG
(US8618299, 40)
Show SMILES Fc1ccc(COc2ccn(-c3ccc4c5CN6CCCC6Cc5[nH]c4c3)c(=O)c2)nc1
Show InChI InChI=1S/C25H23FN4O2/c26-16-3-4-17(27-13-16)15-32-20-7-9-30(25(31)12-20)19-5-6-21-22-14-29-8-1-2-18(29)10-24(22)28-23(21)11-19/h3-7,9,11-13,18,28H,1-2,8,10,14-15H2
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14n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109823
PNG
(US8618299, 41)
Show SMILES FC(F)(F)c1ccc(cn1)-c1ccn(-c2ccc3c4CN5CCCC5Cc4[nH]c3c2)c(=O)c1
Show InChI InChI=1S/C25H21F3N4O/c26-25(27,28)23-6-3-16(13-29-23)15-7-9-32(24(33)10-15)18-4-5-19-20-14-31-8-1-2-17(31)11-22(20)30-21(19)12-18/h3-7,9-10,12-13,17,30H,1-2,8,11,14H2
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14n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109784
PNG
(US8618299, 2 | US8618299, 3 | US8618299, 4)
Show SMILES Cn1c2C3CCCN3CCc2c2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C27H27N3O2/c1-28-25-16-20(9-10-22(25)23-12-14-29-13-5-8-24(29)27(23)28)30-15-11-21(17-26(30)31)32-18-19-6-3-2-4-7-19/h2-4,6-7,9-11,15-17,24H,5,8,12-14,18H2,1H3
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14.9n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109831
PNG
(US8618299, 49)
Show SMILES Cn1c2CCN3CCCC3c2c2ccc(nc12)-n1ccc(cc1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H23F3N4O/c1-31-20-11-13-32-12-2-3-21(32)24(20)19-8-9-22(30-25(19)31)33-14-10-17(15-23(33)34)16-4-6-18(7-5-16)26(27,28)29/h4-10,14-15,21H,2-3,11-13H2,1H3
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15n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109832
PNG
(US8618299, 50)
Show SMILES Cn1c2CC3CCCN3Cc2c2ccc(nc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C26H26N4O2/c1-28-23-14-19-8-5-12-29(19)16-22(23)21-9-10-24(27-26(21)28)30-13-11-20(15-25(30)31)32-17-18-6-3-2-4-7-18/h2-4,6-7,9-11,13,15,19H,5,8,12,14,16-17H2,1H3
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16n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109828
PNG
(US8618299, 46)
Show SMILES Cn1c2CCN3CCCC3c2c2ccc(nc12)-n1ccc(OCc2ccc(F)cc2F)cc1=O
Show InChI InChI=1S/C26H24F2N4O2/c1-30-21-9-11-31-10-2-3-22(31)25(21)19-6-7-23(29-26(19)30)32-12-8-18(14-24(32)33)34-15-16-4-5-17(27)13-20(16)28/h4-8,12-14,22H,2-3,9-11,15H2,1H3
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16n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109834
PNG
(US8618299, 52)
Show SMILES Cn1c2CC3CCCN3Cc2c2ccc(nc12)-n1ccc(cc1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H23F3N4O/c1-31-22-14-19-3-2-11-32(19)15-21(22)20-8-9-23(30-25(20)31)33-12-10-17(13-24(33)34)16-4-6-18(7-5-16)26(27,28)29/h4-10,12-13,19H,2-3,11,14-15H2,1H3
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17n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331255
PNG
(1-(1-(2-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)ethy...)
Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc2n(CCN3CC4CC3CO4)ncc2c1
Show InChI InChI=1S/C26H26N4O3/c31-26-14-23(32-17-19-4-2-1-3-5-19)8-9-29(26)21-6-7-25-20(12-21)15-27-30(25)11-10-28-16-24-13-22(28)18-33-24/h1-9,12,14-15,22,24H,10-11,13,16-18H2
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17.3n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109784
PNG
(US8618299, 2 | US8618299, 3 | US8618299, 4)
Show SMILES Cn1c2C3CCCN3CCc2c2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C27H27N3O2/c1-28-25-16-20(9-10-22(25)23-12-14-29-13-5-8-24(29)27(23)28)30-15-11-21(17-26(30)31)32-18-19-6-3-2-4-7-19/h2-4,6-7,9-11,15-17,24H,5,8,12-14,18H2,1H3
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17.3n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109805
PNG
(US8618299, 23)
Show SMILES Cc1ccc(COc2ccn(-c3ccc4c5C6CCCCN6CCc5n(C)c4c3)c(=O)c2)cn1
Show InChI InChI=1S/C28H30N4O2/c1-19-6-7-20(17-29-19)18-34-22-10-14-32(27(33)16-22)21-8-9-23-26(15-21)30(2)24-11-13-31-12-4-3-5-25(31)28(23)24/h6-10,14-17,25H,3-5,11-13,18H2,1-2H3
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19n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109819
PNG
(US8618299, 37 | US8618299, 38)
Show SMILES Cn1c2CC3CCCCN3Cc2c2ccc(cc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C27H27FN4O2/c1-30-25-13-21(7-8-23(25)24-16-31-10-3-2-4-20(31)12-26(24)30)32-11-9-22(14-27(32)33)34-17-19-6-5-18(28)15-29-19/h5-9,11,13-15,20H,2-4,10,12,16-17H2,1H3
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19n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109824
PNG
(US8618299, 42)
Show SMILES Fc1cc(Cl)ccc1COc1ccn(-c2ccc3c4CN5CCCC5Cc4[nH]c3c2)c(=O)c1
Show InChI InChI=1S/C26H23ClFN3O2/c27-17-4-3-16(23(28)10-17)15-33-20-7-9-31(26(32)13-20)19-5-6-21-22-14-30-8-1-2-18(30)11-25(22)29-24(21)12-19/h3-7,9-10,12-13,18,29H,1-2,8,11,14-15H2
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19n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109790
PNG
(US8618299, 8)
Show SMILES Cn1c2C3CCCCN3CCc2c2ccc(cc12)-n1ccc(OCc2ccc(Cl)cn2)cc1=O
Show InChI InChI=1S/C27H27ClN4O2/c1-30-25-14-20(7-8-22(25)23-10-12-31-11-3-2-4-24(31)27(23)30)32-13-9-21(15-26(32)33)34-17-19-6-5-18(28)16-29-19/h5-9,13-16,24H,2-4,10-12,17H2,1H3
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20n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109827
PNG
(US8618299, 45)
Show SMILES Cn1c2CCN3CCCC3c2c2ccc(nc12)-n1ccc(OCc2ccc(F)cn2)cc1=O
Show InChI InChI=1S/C25H24FN5O2/c1-29-20-9-11-30-10-2-3-21(30)24(20)19-6-7-22(28-25(19)29)31-12-8-18(13-23(31)32)33-15-17-5-4-16(26)14-27-17/h4-8,12-14,21H,2-3,9-11,15H2,1H3
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21n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109804
PNG
(US8618299, 22)
Show SMILES Cn1c2CCN3CCCCC3c2c2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C28H29N3O2/c1-29-24-13-15-30-14-6-5-9-25(30)28(24)23-11-10-21(17-26(23)29)31-16-12-22(18-27(31)32)33-19-20-7-3-2-4-8-20/h2-4,7-8,10-12,16-18,25H,5-6,9,13-15,19H2,1H3
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21n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM109813
PNG
(US8618299, 31)
Show SMILES Cc1ccc(COc2ccn(-c3ccc4c5CN6CCCC6Cc5n(C)c4c3)c(=O)c2)cn1
Show InChI InChI=1S/C27H28N4O2/c1-18-5-6-19(15-28-18)17-33-22-9-11-31(27(32)14-22)21-7-8-23-24-16-30-10-3-4-20(30)12-26(24)29(2)25(23)13-21/h5-9,11,13-15,20H,3-4,10,12,16-17H2,1-2H3
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22n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...


US Patent US8618299 (2013)


BindingDB Entry DOI: 10.7270/Q2JW8CJ9
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50331238
PNG
(4-(benzyloxy)-1-(1-((4,5-dihydro-1H-imidazol-2-yl)...)
Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc2n(CC3=NCCN3)ncc2c1
Show InChI InChI=1S/C23H21N5O2/c29-23-13-20(30-16-17-4-2-1-3-5-17)8-11-27(23)19-6-7-21-18(12-19)14-26-28(21)15-22-24-9-10-25-22/h1-8,11-14H,9-10,15-16H2,(H,24,25)
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22.6n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 20: 7015-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.039
BindingDB Entry DOI: 10.7270/Q2P55NSM
More data for this
Ligand-Target Pair
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