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Compile Data Set for Download or QSAR

Found 56 hits with Last Name = 'shimizu' and Initial = 'r'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006369
PNG
((4R)-6'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2ccc(Cl)cc2[C@@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H9ClN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)/t11-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006362
PNG
(6'-chloro-3',7'-dimethyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2cc(C)c(Cl)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C12H11ClN4O3/c1-5-3-8-6(4-7(5)13)12(17(2)11(20)14-8)9(18)15-10(19)16-12/h3-4H,1-2H3,(H,14,20)(H2,15,16,18,19)
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n/an/a 30n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006372
PNG
(6',8'-dichloro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2c(Cl)cc(Cl)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H8Cl2N4O3/c1-17-10(20)14-7-5(2-4(12)3-6(7)13)11(17)8(18)15-9(19)16-11/h2-3H,1H3,(H,14,20)(H2,15,16,18,19)
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n/an/a 37n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006358
PNG
(8'-fluoro-3'-methyl-1'H,2H,5H-spiro[imidazolidine-...)
Show SMILES CN1C(=O)Nc2c(F)cccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9FN4O3/c1-16-10(19)13-7-5(3-2-4-6(7)12)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 42n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006404
PNG
(6'-chloro-3'-methyl-8'-nitro-1'H,2H,5H-spiro[imida...)
Show SMILES CN1C(=O)Nc2c(cc(Cl)cc2C11NC(=O)NC1=O)[N+]([O-])=O
Show InChI InChI=1S/C11H8ClN5O5/c1-16-10(20)13-7-5(2-4(12)3-6(7)17(21)22)11(16)8(18)14-9(19)15-11/h2-3H,1H3,(H,13,20)(H2,14,15,18,19)
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n/an/a 46n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006403
PNG
(6'-bromo-3'-methyl-1'H,2H,5H-spiro[imidazolidine-4...)
Show SMILES CN1C(=O)Nc2ccc(Br)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9BrN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 52n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006391
PNG
(6'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazolidine-...)
Show SMILES CN1C(=O)Nc2ccc(Cl)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9ClN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 56n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006375
PNG
(6'-chloro-7'-methoxy-3'-methyl-1'H,2H,5H-spiro[imi...)
Show SMILES COc1cc2NC(=O)N(C)C3(NC(=O)NC3=O)c2cc1Cl
Show InChI InChI=1S/C12H11ClN4O4/c1-17-11(20)14-7-4-8(21-2)6(13)3-5(7)12(17)9(18)15-10(19)16-12/h3-4H,1-2H3,(H,14,20)(H2,15,16,18,19)
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n/an/a 59n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006396
PNG
((4R)-6'-fluoro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2ccc(F)cc2[C@@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H9FN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)/t11-/m1/s1
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n/an/a 64n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006392
PNG
(6',8'-dichloro-7'-methoxy-3'-methyl-1'H,2H,5H-spir...)
Show SMILES COc1c(Cl)cc2c(NC(=O)N(C)C22NC(=O)NC2=O)c1Cl
Show InChI InChI=1S/C12H10Cl2N4O4/c1-18-11(21)15-7-4(3-5(13)8(22-2)6(7)14)12(18)9(19)16-10(20)17-12/h3H,1-2H3,(H,15,21)(H2,16,17,19,20)
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n/an/a 72n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006354
PNG
(3'-methyl-6'-nitro-1'H,2H,5H-spiro[imidazolidine-4...)
Show SMILES CN1C(=O)Nc2ccc(cc2C11NC(=O)NC1=O)[N+]([O-])=O
Show InChI InChI=1S/C11H9N5O5/c1-15-10(19)12-7-3-2-5(16(20)21)4-6(7)11(15)8(17)13-9(18)14-11/h2-4H,1H3,(H,12,19)(H2,13,14,17,18)
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n/an/a 73n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006370
PNG
(6',7'-dichloro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2cc(Cl)c(Cl)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H8Cl2N4O3/c1-17-10(20)14-7-3-6(13)5(12)2-4(7)11(17)8(18)15-9(19)16-11/h2-3H,1H3,(H,14,20)(H2,15,16,18,19)
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n/an/a 74n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006389
PNG
(7'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazolidine-...)
Show SMILES CN1C(=O)Nc2cc(Cl)ccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9ClN4O3/c1-16-10(19)13-7-4-5(12)2-3-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 94n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006361
PNG
(6'-fluoro-3'-methyl-1'H,2H,5H-spiro[imidazolidine-...)
Show SMILES CN1C(=O)Nc2ccc(F)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9FN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 100n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006353
PNG
(7'-chloro-3'-methyl-6'-nitro-1'H,2H,5H-spiro[imida...)
Show SMILES CN1C(=O)Nc2cc(Cl)c(cc2C11NC(=O)NC1=O)[N+]([O-])=O
Show InChI InChI=1S/C11H8ClN5O5/c1-16-10(20)13-6-3-5(12)7(17(21)22)2-4(6)11(16)8(18)14-9(19)15-11/h2-3H,1H3,(H,13,20)(H2,14,15,18,19)
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n/an/a 120n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006377
PNG
(8'-amino-6'-chloro-3'-methyl-1'H,2H,5H-spiro[imida...)
Show SMILES CN1C(=O)Nc2c(N)cc(Cl)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H10ClN5O3/c1-17-10(20)14-7-5(2-4(12)3-6(7)13)11(17)8(18)15-9(19)16-11/h2-3H,13H2,1H3,(H,14,20)(H2,15,16,18,19)
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n/an/a 130n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006357
PNG
(6',7',8'-trifluoro-3'-methyl-1'H,2H,5H-spiro[imida...)
Show SMILES CN1C(=O)Nc2c(F)c(F)c(F)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H7F3N4O3/c1-18-10(21)15-7-3(2-4(12)5(13)6(7)14)11(18)8(19)16-9(20)17-11/h2H,1H3,(H,15,21)(H2,16,17,19,20)
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n/an/a 140n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006390
PNG
(3',7'-dimethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2cc(C)ccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C12H12N4O3/c1-6-3-4-7-8(5-6)13-11(19)16(2)12(7)9(17)14-10(18)15-12/h3-5H,1-2H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 220n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006393
PNG
(CHEMBL304257 | ethyl 3'-methyl-2,2',5-trioxo-2',3'...)
Show SMILES CCOC(=O)c1ccc2NC(=O)N(C)C3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C14H14N4O5/c1-3-23-10(19)7-4-5-9-8(6-7)14(18(2)13(22)15-9)11(20)16-12(21)17-14/h4-6H,3H2,1-2H3,(H,15,22)(H2,16,17,20,21)
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n/an/a 240n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM16312
PNG
((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Show SMILES Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
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n/an/a 250n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006387
PNG
(3'-methyl-6',8'-dinitro-1'H,2H,5H-spiro[imidazolid...)
Show SMILES CN1C(=O)Nc2c(cc(cc2C11NC(=O)NC1=O)[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C11H8N6O7/c1-15-10(20)12-7-5(11(15)8(18)13-9(19)14-11)2-4(16(21)22)3-6(7)17(23)24/h2-3H,1H3,(H,12,20)(H2,13,14,18,19)
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n/an/a 260n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006376
PNG
(3'-methyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quina...)
Show SMILES CN1C(=O)Nc2ccccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H10N4O3/c1-15-10(18)12-7-5-3-2-4-6(7)11(15)8(16)13-9(17)14-11/h2-5H,1H3,(H,12,18)(H2,13,14,16,17)
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n/an/a 280n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006364
PNG
((4R)-3'-methyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2ccccc2[C@@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H10N4O3/c1-15-10(18)12-7-5-3-2-4-6(7)11(15)8(16)13-9(17)14-11/h2-5H,1H3,(H,12,18)(H2,13,14,16,17)/t11-/m1/s1
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n/an/a 310n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006355
PNG
(7'-methoxy-3'-methyl-1'H,2H,5H-spiro[imidazolidine...)
Show SMILES COc1ccc2c(NC(=O)N(C)C22NC(=O)NC2=O)c1
Show InChI InChI=1S/C12H12N4O4/c1-16-11(19)13-8-5-6(20-2)3-4-7(8)12(16)9(17)14-10(18)15-12/h3-5H,1-2H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 360n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006366
PNG
(1'-isobutyl-3'-methyl-1'H,2H,5H-spiro[imidazolidin...)
Show SMILES CC(C)CN1C(=O)N(C)C2(NC(=O)NC2=O)c2ccccc12
Show InChI InChI=1S/C15H18N4O3/c1-9(2)8-19-11-7-5-4-6-10(11)15(18(3)14(19)22)12(20)16-13(21)17-15/h4-7,9H,8H2,1-3H3,(H2,16,17,20,21)
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n/an/a 390n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006356
PNG
(3',5'-dimethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2cccc(C)c2C11NC(=O)NC1=O
Show InChI InChI=1S/C12H12N4O3/c1-6-4-3-5-7-8(6)12(16(2)11(19)13-7)9(17)14-10(18)15-12/h3-5H,1-2H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 400n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006367
PNG
(3'-methyl-7'-morpholin-4-yl-6'-nitro-1'H,2H,5H-spi...)
Show SMILES CN1C(=O)Nc2cc(N3CCOCC3)c(cc2C11NC(=O)NC1=O)[N+]([O-])=O
Show InChI InChI=1S/C15H16N6O6/c1-19-14(24)16-9-7-10(20-2-4-27-5-3-20)11(21(25)26)6-8(9)15(19)12(22)17-13(23)18-15/h6-7H,2-5H2,1H3,(H,16,24)(H2,17,18,22,23)
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n/an/a 430n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006374
PNG
(5'-chloro-3'-methyl-6'-nitro-1'H,2H,5H-spiro[imida...)
Show SMILES CN1C(=O)Nc2ccc(c(Cl)c2C11NC(=O)NC1=O)[N+]([O-])=O
Show InChI InChI=1S/C11H8ClN5O5/c1-16-10(20)13-4-2-3-5(17(21)22)7(12)6(4)11(16)8(18)14-9(19)15-11/h2-3H,1H3,(H,13,20)(H2,14,15,18,19)
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n/an/a 470n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006380
PNG
(3'-methyl-7'-nitro-1'H,2H,5H-spiro[imidazolidine-4...)
Show SMILES CN1C(=O)Nc2cc(ccc2C11NC(=O)NC1=O)[N+]([O-])=O
Show InChI InChI=1S/C11H9N5O5/c1-15-10(19)12-7-4-5(16(20)21)2-3-6(7)11(15)8(17)13-9(18)14-11/h2-4H,1H3,(H,12,19)(H2,13,14,17,18)
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n/an/a 480n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006397
PNG
((4S)-6'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2ccc(Cl)cc2[C@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H9ClN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)/t11-/m0/s1
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n/an/a 770n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006386
PNG
(1',3'-dimethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)N(C)C2(NC(=O)NC2=O)c2ccccc12
Show InChI InChI=1S/C12H12N4O3/c1-15-8-6-4-3-5-7(8)12(16(2)11(15)19)9(17)13-10(18)14-12/h3-6H,1-2H3,(H2,13,14,17,18)
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n/an/a 800n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006394
PNG
(3',6'-dimethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2ccc(C)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C12H12N4O3/c1-6-3-4-8-7(5-6)12(16(2)11(19)13-8)9(17)14-10(18)15-12/h3-5H,1-2H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 800n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006401
PNG
(5'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazolidine-...)
Show SMILES CN1C(=O)Nc2cccc(Cl)c2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9ClN4O3/c1-16-10(19)13-6-4-2-3-5(12)7(6)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 860n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006395
PNG
(3'-ethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quinaz...)
Show SMILES CCN1C(=O)Nc2ccccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C12H12N4O3/c1-2-16-11(19)13-8-6-4-3-5-7(8)12(16)9(17)14-10(18)15-12/h3-6H,2H2,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006398
PNG
(1'H,2H,5H-spiro[imidazolidine-4,4'-quinazoline]-2,...)
Show SMILES O=C1NC(=O)C2(N1)NC(=O)Nc1ccccc21
Show InChI InChI=1S/C10H8N4O3/c15-7-10(14-9(17)12-7)5-3-1-2-4-6(5)11-8(16)13-10/h1-4H,(H2,11,13,16)(H2,12,14,15,17)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006406
PNG
(7-methylspiro[5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g...)
Show SMILES CN1C(=O)Nc2cc3OCOc3cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C12H10N4O5/c1-16-11(19)13-6-3-8-7(20-4-21-8)2-5(6)12(16)9(17)14-10(18)15-12/h2-3H,4H2,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006405
PNG
(3'-methyl-2,2',5-trioxo-2',3'-dihydro-1'H-spiro[im...)
Show SMILES CN1C(=O)Nc2ccc(OC(=O)c3ccccc3)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C18H14N4O5/c1-22-17(26)19-13-8-7-11(27-14(23)10-5-3-2-4-6-10)9-12(13)18(22)15(24)20-16(25)21-18/h2-9H,1H3,(H,19,26)(H2,20,21,24,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006399
PNG
((4S)-3'-methyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2ccccc2[C@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H10N4O3/c1-15-10(18)12-7-5-3-2-4-6(7)11(15)8(16)13-9(17)14-11/h2-5H,1H3,(H,12,18)(H2,13,14,16,17)/t11-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006352
PNG
(3'-amino-1'H,2H,5H-spiro[imidazolidine-4,4'-quinaz...)
Show SMILES NN1C(=O)Nc2ccccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C10H9N5O3/c11-15-9(18)12-6-4-2-1-3-5(6)10(15)7(16)13-8(17)14-10/h1-4H,11H2,(H,12,18)(H2,13,14,16,17)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006383
PNG
((4S)-6'-fluoro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2ccc(F)cc2[C@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H9FN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)/t11-/m0/s1
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n/an/a 4.50E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006360
PNG
(6'-methoxy-3'-methyl-1'H,2H,5H-spiro[imidazolidine...)
Show SMILES COc1ccc2NC(=O)N(C)C3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C12H12N4O4/c1-16-11(19)13-8-4-3-6(20-2)5-7(8)12(16)9(17)14-10(18)15-12/h3-5H,1-2H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006381
PNG
(3'-methyl-2,2',5-trioxo-2',3'-dihydro-1'H-spiro[im...)
Show SMILES CN1C(=O)Nc2ccc(OC(=O)C=Cc3ccccc3)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C20H16N4O5/c1-24-19(28)21-15-9-8-13(11-14(15)20(24)17(26)22-18(27)23-20)29-16(25)10-7-12-5-3-2-4-6-12/h2-11H,1H3,(H,21,28)(H2,22,23,26,27)
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n/an/a 6.20E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006363
PNG
((3'-methyl-2,2',5-trioxo-2',3'-dihydro-1H,1'H-spir...)
Show SMILES CN1C(=O)Nc2ccccc2C11NC(=O)N(CC(O)=O)C1=O
Show InChI InChI=1S/C13H12N4O5/c1-16-11(21)14-8-5-3-2-4-7(8)13(16)10(20)17(6-9(18)19)12(22)15-13/h2-5H,6H2,1H3,(H,14,21)(H,15,22)(H,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006359
PNG
(3'-methyl-2-thioxo-1'H,5H-spiro[imidazolidine-4,4'...)
Show SMILES CN1C(=O)Nc2ccccc2C11NC(=S)NC1=O
Show InChI InChI=1S/C11H10N4O2S/c1-15-10(17)12-7-5-3-2-4-6(7)11(15)8(16)13-9(18)14-11/h2-5H,1H3,(H,12,17)(H2,13,14,16,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006365
PNG
(3'-hydroxy-1'H,2H,5H-spiro[imidazolidine-4,4'-quin...)
Show SMILES ON1C(=O)Nc2ccccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C10H8N4O4/c15-7-10(13-8(16)12-7)5-3-1-2-4-6(5)11-9(17)14(10)18/h1-4,18H,(H,11,17)(H2,12,13,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006384
PNG
(2'-amino-3-methyl-1H,4'H-spiro[quinazoline-4,5'-[1...)
Show SMILES CN1C(=O)Nc2ccccc2C11SC(N)=NC1=O
Show InChI InChI=1S/C11H10N4O2S/c1-15-10(17)13-7-5-3-2-4-6(7)11(15)8(16)14-9(12)18-11/h2-5H,1H3,(H,13,17)(H2,12,14,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006379
PNG
(3'-isopropyl-1'H,2H,5H-spiro[imidazolidine-4,4'-qu...)
Show SMILES CC(C)N1C(=O)Nc2ccccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C13H14N4O3/c1-7(2)17-12(20)14-9-6-4-3-5-8(9)13(17)10(18)15-11(19)16-13/h3-7H,1-2H3,(H,14,20)(H2,15,16,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006368
PNG
(3'-benzyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quina...)
Show SMILES O=C1NC(=O)C2(N1)N(Cc1ccccc1)C(=O)Nc1ccccc21
Show InChI InChI=1S/C17H14N4O3/c22-14-17(20-15(23)19-14)12-8-4-5-9-13(12)18-16(24)21(17)10-11-6-2-1-3-7-11/h1-9H,10H2,(H,18,24)(H2,19,20,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006388
PNG
(3'-phenyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quina...)
Show SMILES O=C1NC(=O)C2(N1)N(C(=O)Nc1ccccc21)c1ccccc1
Show InChI InChI=1S/C16H12N4O3/c21-13-16(19-14(22)18-13)11-8-4-5-9-12(11)17-15(23)20(16)10-6-2-1-3-7-10/h1-9H,(H,17,23)(H2,18,19,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006378
PNG
(3,3'-dimethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-q...)
Show SMILES CN1C(=O)NC(=O)C11N(C)C(=O)Nc2ccccc12
Show InChI InChI=1S/C12H12N4O3/c1-15-10(18)13-8-6-4-3-5-7(8)12(15)9(17)14-11(19)16(12)2/h3-6H,1-2H3,(H,13,18)(H,14,17,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
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