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Found 11 of ic50 for monomerid = 123747
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM123747(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50:  129nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM123747(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50:  129nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM123747(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphorimaging methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase D(Streptomyces chromofuscus)
Roxbury Community College

LigandPNGBDBM123747(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50:  250nMpH: 8.0Assay Description:A NaOH stock solution (50 mM) was standardized with KHP then diluted in Millipore water (10-fold serial dilutions) then used to hold the pH constant ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase D2(Homo sapiens (Human))
University Of Massachusetts Boston

LigandPNGBDBM123747(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50:  290nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase D1(Homo sapiens (Human))
University Of Massachusetts Boston

LigandPNGBDBM123747(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50:  550nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM123747(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50:  636nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM123747(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50:  636nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhospholipase D(Streptomyces sp. PMF)
University Of Massachusetts Boston

LigandPNGBDBM123747(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50:  650nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
California Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM123747(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of p97 in human HeLa cells assessed as reduction in proteasomal turnover of p97-dependent reporter substrate UbG76V-GFP incubated for 120 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
California Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM123747(1-(tert-butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed