Found 215 of ic50 for monomerid = 13530 
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of HER2 (unknown origin) incubated for 1 hr in presence of ATP by Kinase-Glo Plus luminescence kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.110nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 1 hr in presence of ATP by Kinase-Glo Plus luminescence kinase assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of wild type Bcr-AblMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 2nMAssay Description:Inhibition of PDGFRA (unknown origin)More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PDGFRalpha (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 10.8nMAssay Description:Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition constant against Adenosine A2a receptorMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of BCR/ABL (unknown origin) after 40 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of Bcr-Abl (unknown origin) after 60 mins by luminescent kinase assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Concentration required to inhibit the activity of K+ stimulated gastric ATPaseMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of PDGFRalpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Technical University Of Dortmund
Curated by ChEMBL
Technical University Of Dortmund
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human wild-type ABL (Ser229 to Gln513)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) pr...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of BCR-ABL phosphorylation in human K562 cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1 [1-999,Q252H](Homo sapiens (Human))
The Scripps Research Institute
The Scripps Research Institute
Affinity DataIC50: 27nMpH: 7.5Assay Description:An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
Affinity DataIC50: 30.7nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Technical University Of Dortmund
Curated by ChEMBL
Technical University Of Dortmund
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibitory concentration against v-Abl tyrosine kinaseMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of BCR-ABL kinase (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Technical University Of Dortmund
Curated by ChEMBL
Technical University Of Dortmund
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of v-Abl tyrosine kinase.More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of Bcr-Abl (unknown origin)More data for this Ligand-Target Pair
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Technical University Of Dortmund
Curated by ChEMBL
Technical University Of Dortmund
Curated by ChEMBL
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Mcgill University/Royal Victoria Hospital
Curated by ChEMBL
Mcgill University/Royal Victoria Hospital
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of Abl tyrosine kinaseMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of cKIT (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition in presence of ATP...More data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of autophosphorylation of DDR1 expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Technical University Of Dortmund
Curated by ChEMBL
Technical University Of Dortmund
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of inactive wild type His-tagged ABL (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells assessed as reduct...More data for this Ligand-Target Pair
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of kinobead binding to NQO2 in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of SCF-induced phosphorylation of c-Kit (unknown origin) in MO7e cells by TR-FRET assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration against platelet-derived growth factor receptorMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of the platelet-derived growth factor receptor.More data for this Ligand-Target Pair
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of c-Kit (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of recombinant N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) (unknown origin) expressed in baculovir...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of wild type BCR/ABL (unknown origin) measured after 60 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibition of PDGFRalpha (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of human PDGFRalpha autophosphorylation in human A31 cells by ELISAMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of PDGFRbeta autophosphorylation in human A31 cells by ELISAMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of Bcr-Abl (unknown origin) after 1 hr by luminescence assayMore data for this Ligand-Target Pair
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 82nMAssay Description:Inhibition of full length human His6/GST-tagged NQO2 expressed in Escherichia coli Tuner(DE3)pLysS using menadione as substrate and CCHP as co-substr...More data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of kinobead binding to DDR1 in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Inhibition of human KIT autophosphorylation in human GIST882 cells by ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Technical University Of Dortmund
Curated by ChEMBL
Technical University Of Dortmund
Curated by ChEMBL
Affinity DataIC50: 98nMAssay Description:Inhibition of human recombinant wild type ABL1 expressed in insect cells after 30 mins by FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Technical University Of Dortmund
Curated by ChEMBL
Technical University Of Dortmund
Curated by ChEMBL
Affinity DataIC50: 98nMAssay Description:Inhibition of Abl (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against c-Kit wild type expressed in recombinant baculovirusMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Tu Dortmund University
Curated by ChEMBL
Tu Dortmund University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against c-KitMore data for this Ligand-Target Pair
